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Biomechanics Lab
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The lab uses mechanics and computation to uncover how blood and cells move.
AboutAbout the lab
Reading the flows inside the body through mechanics.
The Biomechanics Lab studies the structure and function of biological tissues and cells from a mechanical perspective.
Its themes include thrombosis, the filtration mechanism of the kidney, cell motion and deformation, and the microcirculation.
The lab approaches problems of blood clots and cells through both experiments and computational modeling.
It aims to create new foundational technologies that can solve problems in medicine and engineering.
Key terms
- Microcirculation
- The flow of blood through the thin vessels found throughout the body, such as capillaries
- Particle method
- A simulation approach that calculates flow and deformation as the motion of many particles
- Shear rate
- The magnitude of the difference in velocity from place to place within a flow
NewsLab news
A master's student received the Young Researcher Outstanding Presentation Fellow Award from the Japan Society of Mechanical Engineers
A master's student received an Outstanding Presentation Award for Young Researchers at the 34th Bio-Frontier Conference
Professor Tsubota received the Best Presenter Award at the 12th Asian-Pacific Conference on Biomechanics
ResearchResearch themes
The lab aims to understand the structure and function of biological tissues and cells mechanically, and to build on that understanding to create foundational technologies that can solve problems in medicine and engineering. It investigates thrombosis, the filtration mechanism of the kidney, cell motion and deformation, and the microcirculation through both experiments and computational modeling.
*Illustrative imageDeformation and Motion of Red Blood Cells
The motion and deformation of a red blood cell depend strongly on mechanical conditions that can be modeled as an outer viscoelastic membrane enclosing an inner viscous fluid. Using particle-method simulations, the lab studies how a red blood cell's mechanical properties and natural state affect its motion and deformation in simple shear flow.
*Illustrative imageThrombus Formation Experiments in Microchannels
Stagnation of blood flow is a major cause of blood clots forming in veins. In thrombus formation experiments using microchannels and a blood-mimicking fluid, the lab studies the relationship between flow parameters such as flow velocity and shear rate and thrombus formation.
*Illustrative imageSimulation of Microcirculatory Networks
In the microcirculation, the diameter of blood vessels is close to the size of red blood cells, so the characteristics of blood flow depend strongly on the mechanical behavior of individual red blood cells. Using blood flow simulations that take the deformation and motion of red blood cells into account, the lab studies both the physiological and pathological behavior of the microcirculation.
*Illustrative imageParticle-Method Simulation of Thrombus Formation and Drug Efficacy
Antithrombotic drugs used to treat thrombosis can cause serious side effects, so the dosage should be kept to the necessary minimum. The lab represents the action of a drug under blood flow with particle-method simulations and aims to determine appropriate dosages by comparing the results with data from animal experiments.
MembersFaculty
The members of the Biomechanics Lab consist of faculty, administrative staff, and master's and undergraduate students.As of 2024
- ProfessorKenichi Tsubota
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Belgrad - Museum of Science and Technology - Electron microscope ARL” Александр Сигачёв / CC0 (cropped)
- Deformation and Motion of Red Blood Cells: “Red White Blood cells” Electron Microscopy Facility at The National Cancer Institute at Frederick (NCI-Frederick) / Public domain (cropped)
- Thrombus Formation Experiments in Microchannels: “FISHchip” Vjsieben at English Wikipedia / Public domain (cropped)
- Simulation of Microcirculatory Networks: “Illu capillary microcirculation-ja” Arcadian; Tossh_eng for japanese labels. / CC BY-SA 3.0 (cropped)
- Particle-Method Simulation of Thrombus Formation and Drug Efficacy: “Fluid simulation created using Blender 3D” Original uploader was Charybdis at en.wikibooks / CC BY-SA 3.0 (cropped)
- Related lab (Electrical Energy Applications Lab): “Superconductor” Edosz2010 / CC BY 4.0 (cropped)
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