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Chemical Biology Lab
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A lab that investigates the target molecules and mechanisms of action of natural compounds.
AboutAbout the lab
Finding the targets of natural compounds and uncovering how they act.
The lab conducts chemical biology research that uses natural compounds acting on animal cells to identify their target molecules and analyze their mechanisms of action.
It focuses on compounds that show intriguing bioactivity in cells but whose target molecules are unknown, and investigates even how they bind to their targets, with the aim of laying the groundwork for developing new drugs.
The lab is recruiting members who are interested in research using animal cells or yeast.
Key terms
- Chemical biology
- Research that uses chemical compounds as tools to investigate the target molecules they act on and their mechanisms of action
- Tight junction
- A structure between epithelial cells that forms the epithelial barrier. Some research aims to open it temporarily with drugs
- Microtubule
- A tubular structure inside cells. Microtubule motors such as Eg5, which acts during cell division (mitosis), bind to it to function
NewsLab news
View More ↗ResearchResearch themes
Many compounds that show bioactivity in cells have target molecules that remain unknown. This lab aims to identify the target molecules of such compounds and to investigate how they bind to those targets, in order to lay the groundwork for developing new drugs.
*Illustrative imageDrugs that open tight junctions
The lab studies how drugs act that loosen the epithelial barrier only temporarily while a drug is being administered, and let it recover after the drug has passed through. Targets include capsaicin, as a means of delivering biopharmaceuticals by transdermal, oral, or nasal administration.
*Illustrative imageMechanisms of drugs that act on microtubules
The lab studies microtubule-targeting drugs, which are also used as antitumor agents. Pironetin is known to bind covalently to α-tubulin, and terpendole E is known to inhibit Eg5, a microtubule motor that acts during mitosis.
MembersFaculty
The lab's members consist of faculty and master's students.
- ProfessorTakeo Usui
- Assistant ProfessorMinagi Mukaiyama
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Epithelial cells in PAP Smear” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped)
- Drugs that open tight junctions: “Junctional complex and pinocytotic vesicles - embryonic brain-TEM” Louisa Howard, Miguel Marin-Padilla / Public domain (cropped)
- Mechanisms of drugs that act on microtubules: “Microtubules in Primary Mouse Embryonic Fibroblasts” Howard Vindin / CC BY 4.0 (cropped)
- Related lab (Organelle Cell Biology Lab): “Fluorescence Microscopy of Mycobacterium tuberculosis Following Auramine O Staining. 03” Siduduziwe Nxumalo / CC BY-SA 4.0 (cropped)
- Related lab (Niwa Lab): “Fruit fly (Diptera, Tephritidae) ( )” Insects Unlocked / CC0 (cropped)
- Related lab (Plant Physiology Lab): “Greenhouse at Plants Galore - geograph.org.uk - 4478771” Derek Harper / CC BY-SA 2.0 (cropped)
- Related lab (Plant Molecular Physiology Lab): “ISS-56 Arabidopsis plants inside the Advanced Plant Habitat (1)” NASA / Public domain (cropped)
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