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Molecular Phylogenetics Lab
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This lab uses sequence data to uncover how eukaryotic microbes evolved.
AboutAbout the lab
Uncovering microbial evolution through sequence comparison
The Microbial Molecular Evolution Lab tackles a range of unsolved questions about the evolution of microbes, especially eukaryotic microbes.
Its main method is molecular phylogenetic analysis, which analyzes nucleic acid and amino acid sequences.
The lab investigates the phylogenetic relationships among the major groups of eukaryotes and the evolution of translation elongation factors.
The lab's website is published as the personal homepage of Professor Yuji Inagaki.
Key terms
- Molecular phylogenetic analysis
- An analysis that compares nucleic acid or amino acid sequences to infer the phylogenetic relationships among organisms
- Translation elongation factor
- A type of GTPase (GTP-hydrolyzing protein) involved in protein synthesis. Examples include EF-1α
- Horizontal gene transfer
- The movement of genes between distantly related species, rather than being passed down from parent to offspring
ResearchResearch themes
The Microbial Molecular Evolution Lab investigates the evolutionary history of eukaryotic microbes through molecular phylogenetic analysis of nucleic acid and amino acid sequence data. Its research covers the phylogenetic relationships among the major groups of eukaryotes and the evolution of translation elongation factors. The content of the research page dates from around 2010.
*Illustrative imageInferring the Deep Phylogeny of Eukaryotes
The lab aims to clarify the phylogenetic relationships among the major groups of eukaryotes by analyzing data from multiple genes. It is advancing analyses of organisms that belong to, or may belong to, the Hacrobia (haptophytes and cryptophytes).
*Illustrative imageEvolution of Translation Elongation Factors
The lab studies the evolution of the translation elongation factor EF-1α, which is involved in protein synthesis, and of related proteins. Genes for EF-1α-like proteins (EFL) have been proposed to undergo horizontal gene transfer between distantly related eukaryotes, and the lab is surveying their distribution and biochemically testing whether they perform the same function as EF-1α.
MembersFaculty
- ProfessorYuji Inagaki
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Darwin tree” Charles Darwin / Public domain (cropped)
- Inferring the Deep Phylogeny of Eukaryotes: “CSIRO ScienceImage 6743 SEM Cryptophyte” CSIRO, CSIRO / CC BY 3.0 (cropped)
- Evolution of Translation Elongation Factors: “Ribosome Translation” CNX OpenStax / CC BY 4.0 (cropped)
- Related lab (Computational Biophysics (Ryuhei Harada) Lab): “Anton supercomputer” Matt Simmons / CC BY 2.0 (cropped)
- Related lab (Structural Biology Lab): “Using X-ray diffractometer to solve the 3D structure of membrane proteins of the flagellar system ( )” OIST from Onna Village, Japan / CC BY 2.0 (cropped)
- Related lab (Cell Biology Lab (Inaba)): “Tunicate colony Nick Hobgood” Nhobgood / CC BY-SA 3.0 (cropped)
- Related lab (Eukaryotic Microbial Genomics Lab (Shigekatsu Suzuki)): “Diatoms through the microscope” Prof. Gordon T. Taylor, Stony Brook University / Public domain (cropped)
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