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Developmental Genetics Lab
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A lab that uses ascidians to explore the mechanisms of development, metamorphosis, and evolution in chordates.
AboutAbout the lab
Exploring how the body is built, through ascidian genetics.
Sasakura Lab studies the mechanisms of development, metamorphosis, and evolution in chordates, using ascidians as its main research material.
Ascidians are the invertebrates most closely related to vertebrates, and they retain the basic body plan of chordates within a simple genome and body organization.
With transgenic ascidians and genome editing, the lab can visualize ascidian cells and tissues in living animals and observe individuals in which gene function has been lost.
Research is carried out at a marine biological station with abundant access to seawater, where many strains are maintained.
Key terms
- Chordates
- A group of animals that includes ascidians and vertebrates. Ascidian larvae have a notochord and a dorsal nerve cord.
- Transposon
- A DNA sequence that can move within the genome. This lab uses Minos to insert foreign DNA into the genome.
- Genome editing
- A technology for rewriting targeted locations in the genome. TALEN and CRISPR/Cas9 are used to disrupt gene function.
ResearchResearch themes
Sasakura Lab examines how genes function in ascidians in order to clarify how the chordate body is formed, undergoes metamorphosis, and has evolved. The lab conducts its research while rearing strains created with transgenic and genome-editing technologies at a marine biological station with access to seawater.
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MembersFaculty
Sasakura Lab's members consist of faculty, researchers, technical staff, and doctoral and master's students.
- ProfessorYasunori Sasakura
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Coral on display at Mote Marine Laboratory 2” Will Pittenger / CC BY-SA 3.0 (cropped)
- Creating Transgenic Ascidians with Transposons: “Cionaintestinalis” perezoso / CC BY-SA 3.0 (cropped)
- Related lab (Wada Lab (Animal Phylogeny and Evolution, Evolutionary Developmental Biology)): “Invertebrate montage (2022)” File:Jelly cc11.jpg: Paroxysm~commonswiki (uploader), Original by Dan Parsons [1] File:Fromia indica HI09-0187.JPG: FredD, Original by François Michonneau File:Sepioteuthis sepioidea (Caribbean Reef Squid).jpg: Nhobgood File:Drosophila melanogaster Proboscis.jpg: Sanjay Acharya File:Aplysina lacunosa.jpg: Loopy30 (uploader), Original by jbrasher [2] File:Pseudobiceros_hancockanus.jpg: Jnpet File:Sucking leech.jpg: GlebK File:Sea Squirts (Polycarpa aurata) ( ).jpg: Josve05a (uploader), Original by Bernard DUPONT [3] File:SEM image of Milnesium tardigradum in active state - journal.pone.0045682.g001-2.png: Daniel Mietchen (uploader), Original by Schokraie E, Warnken U, Hotz-Wagenblatt A, Grohme MA, Hengherr S, et al. (2012) / CC BY-SA 4.0 (cropped)
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