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Newt Retina Regeneration Lab
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A lab that uncovers how newts regenerate their bodies at the molecular and cellular levels.
AboutAbout the lab
Research aimed at saving people from severe injury
The Newt Retina Regeneration Lab (Chiba Lab) studies how the Japanese fire-bellied newt regenerates its body, at the molecular and cellular levels.
The website describes the newt as a vertebrate that fully regenerates even the tissues of its limbs, tail (including the spinal cord), jaw, eyes (lens and retina), brain, and heart.
By bringing out the differences between newts and humans, the lab aims to open a path for applying this animal's regeneration strategies to medicine.
On the lab's website, it is presented under the name "Regeneration Physiology Lab."
Key terms
- Dedifferentiation
- A process in which a cell with a determined role returns to a state closer to an immature one
- Transdifferentiation
- A process in which one type of cell changes into another type of cell
- Model organism
- An animal for which information and technical infrastructure have been developed to make it easy to use in research
ResearchResearch themes
The lab aims to uncover how newts regenerate their bodies at the molecular and cellular levels and, using the differences from humans, to open a path for applying this animal's regeneration strategies to medicine. In parallel, it is building information and technology infrastructure to turn the Japanese fire-bellied newt into a resource and a model organism.
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MembersFaculty
The Regeneration Physiology Lab consists of faculty members, doctoral, master's, and undergraduate students, research students, and faculty members collaborating on research.As of 2026
- ProfessorChikafumi Chiba
- Assistant ProfessorMartin Casco
- Project Assistant Professor (Early Career Support)Shota Shiga
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Cynops pyrrhogaster (under)” Alpsdake / CC BY-SA 4.0 (cropped)
- Exploring regeneration by comparing newts and humans: “Cynops pyrrhogaster sasayamae female” Wuchthans / Public domain (cropped)
- Related lab (Shiga Lab): “Human umbilical vein endothelial cells” BigLew99 / CC BY-SA 4.0 (cropped)
- Related lab (Animal Physiology Lab (Casco-Robles)): “Cynops pyrrhogaster (under s4)” Alpsdake / CC BY-SA 4.0 (cropped)
- Related lab (Maruo Lab): “SH-SY5Y cells cultured on a 384 microwell plate, imaged with ZEISS Celldiscoverer )” ZEISS Microscopy from Germany / CC BY 2.0 (cropped)
- Related lab (Chiba Lab): “Stain for SDS-PAGE gel” Andra MIhali from New York City, United States / CC BY-SA 2.0 (cropped)
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