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Neurobiology Lab (Vogt)
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The lab investigates the role of sleep in the brain's neurons and in learning.
AboutAbout the lab
Exploring the sleeping brain, starting from its neurons
The lab of Associate Professor Kaspar Manuel Vogt uses mice to study how sleep affects the function of neurons in the brain and learning.
Its research fields are neurochemistry/neuropharmacology and neurophysiology/neuroscience in general, with the cerebral cortex, slow waves, imaging, and sleep as its research keywords.
The lab has shown, using optogenetic methods that rely on light-responsive proteins, that neurons in the cerebral cortex respond more strongly during slow-wave sleep than during wakefulness.
Currently, the lab is comparing motor learning, and synaptic changes in a brain region that controls movement, between well-rested mice and sleep-deprived mice.
Key terms
- Cerebral cortex
- The outermost layer of the brain. It underlies consciousness and is the source of slow waves, the brain waves that appear during deep sleep
- Slow-wave sleep
- Deep sleep in which brain waves called slow waves appear. During it, body movement and awareness of the surroundings are almost entirely lost
ResearchResearch themes
The lab uses experiments in mice to study what happens in the brain during sleep and how sleep supports learning and brain plasticity. It uses the activity of neurons in the cerebral cortex and synaptic changes as clues.
*Illustrative imageSleep, motor learning, and synapses
The lab compares learning behavior and brain function between mice that have slept enough and mice deprived of sleep. It measures the learning of a forelimb reaching task with a high-speed camera, and examines how synapses change in the region that controls movement.
Excitability of the cerebral cortex during slow-wave sleep
Activity in the cerebral cortex has long been thought to be suppressed during slow-wave sleep, and the lab has tested whether this is correct. When part of the cortex was activated with light, neurons responded more strongly during slow-wave sleep than during wakefulness.
MembersFaculty
- Associate ProfessorVOGT Kaspar Manuel
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Sleeping baby, Baby's sleep, Colors, Moscow, Russia” Vyacheslav Argenberg / CC BY 4.0 (cropped)
- Sleep, motor learning, and synapses: “Synapse neuro-neuronale” Savant-fou / CC BY-SA 3.0 (cropped)
- Related lab (Animal Physiology Lab (Casco-Robles)): “Cynops pyrrhogaster (under s4)” Alpsdake / CC BY-SA 4.0 (cropped)
- Related lab (Genome Microbiology Lab): “Enterobacteria phage T2 transmission electron micrograph” SnaxMikn / CC BY-SA 4.0 (cropped)
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- Related lab (Sakurai Lab): “Patch clamp schematic 2” PeaBrainC / CC BY-SA 4.0 (cropped)
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