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Synthetic Chemistry of Biofunctional Molecules Lab
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The lab uses the power of chemistry to create molecules that control gene expression.
AboutAbout the lab
Unraveling the life sciences through the power of chemistry
The Synthetic Chemistry of Biofunctional Molecules research group (Nagatsugi Lab) designs and synthesizes functional molecules based on organic chemistry, and aims to develop methods for chemically controlling gene expression.
With the goal of chemical biology, which unravels the life sciences through chemistry, the lab develops chemical tools to control and elucidate gene expression inside cells.
Its listed research keywords include organic synthesis, nucleic acid chemistry (the chemistry of DNA and RNA), antisense, miRNA, RNA-targeted drug discovery, supramolecular chemistry, and photocatalysis.
Key terms
- Chemical biology
- A research field that uses chemical methods to elucidate biological phenomena
- Gene expression
- The process by which proteins and other products are made in a cell based on the information in genes
- miRNA
- A type of small RNA found in cells that is involved in regulating gene activity
NewsLab news
Collaborative research by Associate Professor Onizuka and others with the Frontier Research Institute for Interdisciplinary Sciences and Shizuoka University was published in Communications Chemistry
Collaborative research by doctoral students and others was published in RSC Chemical Biology
Research by Assistant Professor Yamano, Associate Professor Onizuka, and others was accepted by Communications Chemistry
Collaborative research by Associate Professor Onizuka and others with Kyoto University, the University of Tokyo, and a company was published in Nature Communications
Research by a doctoral student, Associate Professor Onizuka, and others was accepted by Communications Chemistry
ResearchResearch themes
With the goal of chemical biology, which unravels the life sciences through chemistry, the lab aims to develop chemical tools to control and elucidate gene expression inside cells. Based on organic chemistry, it designs and synthesizes functional molecules and works on developing methods to chemically control gene expression.
View More ↗MembersFaculty
The lab's members consist of faculty, doctoral and master's students, secretaries, and technical staff.As of 2025
- ProfessorFumi Nagatsugi
- Associate ProfessorKazumitsu Onizuka
- Assistant ProfessorYuhei Yamano
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “DNA comparisons spacefill” RWhitwam / CC BY-SA 4.0 (cropped)
- Related lab (量子ビーム構造生物化学): “Esrf chartreuse 01” Marco Cammarata / CC BY-SA 4.0 (cropped)
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