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Nano/Micro Analytical Chemistry Lab
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A lab that measures chemical phenomena in tiny nano- and micro-scale spaces.
AboutAbout the lab
Measuring the chemistry that takes place in tiny spaces
The Nano/Micro Analytical Chemistry Lab studies chemical phenomena that occur in tiny spaces on the scale of nanometers and micrometers, as well as analytical chemistry that makes use of those spaces.
The lab fabricates its own experimental devices by microfabrication and handles minute amounts of liquid and tiny water droplets.
Its work includes analyzing the process by which proteins form fibrils, bioanalysis using tiny water droplets, and developing portable analytical instruments.
On the lab's website, it is presented under the name “Hibara Lab.”
Key terms
- Microfluidic device
- A small device in which fine channels and tiny chambers are made on a substrate, so that chemical operations and analysis can be performed with small amounts of liquid.
- Spontaneous emulsification
- An emulsification phenomenon in which tiny droplets form naturally at the interface where liquids meet, without vigorous stirring.
- Immunoassay
- An analytical method that uses the property of antibodies binding to specific substances to measure substances contained in samples such as serum.
NewsLab news
A paper by Associate Professor Mao Fukuyama and colleagues was accepted by Talanta
A paper by Associate Professor Mao Fukuyama and colleagues was accepted by the Journal of the American Chemical Society
A student received an Excellent Presentation Award at the Joint Meeting of the Hokkaido and Tohoku Branches of the Biophysical Society of Japan
Associate Professor Mao Fukuyama received the Scientific Measurement Promotion Award from the Institute of Multidisciplinary Research for Advanced Materials
A master's student received an Excellent Presentation Award at the 50th Meeting of the Japan Society for Chemistry and Micro-Nano Systems
ResearchResearch themes
The lab studies chemical phenomena that occur in tiny spaces on the scale of nanometers and micrometers, as well as analytical chemistry that uses those spaces. By elucidating solution chemistry and interfacial chemistry in tiny spaces and developing new analytical methods, it aims to establish microspace chemistry as an academic discipline.
*Illustrative imageAnalysis of nucleation in protein fibril formation
The lab studies nucleation, the first step in the formation of protein fibrils, which are important for understanding diseases such as Alzheimer's disease. Using microfluidic devices to run many experiments at the same time, it has developed a method to detect individual nucleation events.
*Illustrative imageBioanalysis using micro water droplets
The lab works on techniques that manipulate tiny water droplets formed in oil inside microfluidic devices and use them for chemical and biological analysis. It has developed a new sample pretreatment procedure that uses a phenomenon called spontaneous emulsification.
*Illustrative imageDevelopment of a portable immunoassay device
The lab is developing an easy-to-operate portable device that combines fluorescence polarization immunoassay with a microfluidic device, in collaboration with Hokkaido University, Tokyo Institute of Technology, Tianma Japan, Ltd., and Komatsu University. It can measure biomarkers and other substances in human serum within 30 minutes.
MembersFaculty
The members of the Nano/Micro Analytical Chemistry Lab consist of faculty members, joint researchers, technical staff, academic researchers, administrative assistants, dispatched staff (technical assistants), and doctoral, master's, and undergraduate students.As of 2026
- Professor (Concurrent)Hitoshi Kasai
- Associate ProfessorMao Fukuyama
- Assistant ProfessorYao Li
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Modified Flow Focusing Device” Kimbalm / CC BY-SA 4.0 (cropped)
- Analysis of nucleation in protein fibril formation: “Fluorescence microscopy of the oral cancer cells” Korinna / CC BY 4.0 (cropped)
- Bioanalysis using micro water droplets: “Microfluidics Diagram (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Development of a portable immunoassay device: “Pipette gallery” User:Squidonius, myself, and User:Beliason (assumed). / CC BY-SA 4.0 (cropped)
- Related lab (ナノ機能物性化学): “Molecular-beam epitaxy 412 RIBER system at LAAS-CNRS” QGravelier / CC BY-SA 4.0 (cropped)
- Related lab (走査プローブ計測技術): “Scanning probe microscope ( )” Oak Ridge National Laboratory / CC BY 2.0 (cropped)
- Related lab (細胞機能分子化学): “Green Fluorescence Microscopy” Jamil Baza / CC BY 4.0 (cropped)
- Related lab (有機・バイオナノ材料): “Air Force Research Laboratory chemists collaborate with MIT on nanomaterial advancement with flow chemistry (7087055)” U.S. Air Force AFRL by Jonathan Taulbee / Public domain (cropped)
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