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Uozumi Lab
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A lab that explores how life adapts to its environment, starting from ion transport across biological membranes.
AboutAbout the lab
The mechanisms and creation of biomolecules
The Uozumi Lab studies, at the molecular and genetic levels, phenomena that occur in biological membranes.
Biological membranes are regions of the cell that distinguish and select substances, and that produce and convert energy for the organism.
The lab aims to understand the mechanisms of the ability to adapt to the environment, and of proliferation, growth, and differentiation.
It will connect the knowledge gained to bioengineering and biotechnology that take the global environment into account.
Key terms
- Biological membrane
- A membrane that surrounds cells and the small organelles inside cells, and selectively controls the passage of substances
- Ion transporter
- A protein in biological membranes that passes or carries ions such as sodium and potassium
- Biostimulant
- A material that enhances the adaptability to the environment that plants naturally have, working differently from fertilizers and pesticides
NewsLab news
A paper by Assistant Professor Muraoka was published in Science Advances
A paper involving the lab was published in Nature Communications
A paper by a doctoral student was published in Journal of Biological Chemistry
A paper by doctoral students and others was published in Proceedings of the National Academy of Sciences (PNAS)
A paper by Project Assistant Professor Ellen and others was published in Biosci. Biotechnol. Biochem.
ResearchResearch themes
The lab clarifies the phenomena unfolding in biological membranes at the molecular and genetic levels, aiming to make molecules that carry out biological functions usable. Using ion transport as a clue, it investigates how organisms, from plants to cyanobacteria, E. coli, and yeast, adapt to environmental change.
*Illustrative imageIon Transporters for Environmental Adaptation
Aiming to create plants that tolerate drought, dehydration, and salt damage, the lab studies ion transporters at the molecular level. It found that HKT1 in Arabidopsis removes sodium that has entered the root xylem and prevents it from moving to the aboveground parts, protecting seed formation in flower buds from high salt concentrations.
*Illustrative imageDeveloping Biostimulants
The lab searches chemical libraries for compounds that regulate the activity of ion channels and transporters. It has shown that green tea catechins regulate the activity of an ion channel involved in the opening and closing of stomata, and aims to develop biostimulants that enhance plants' own ability to adapt to the environment.
*Illustrative imageResponse Mechanisms of Photosynthetic Organisms
The lab investigates how plants and cyanobacteria, the origin of chloroplasts, respond to the environment, through ion transporters and sulfur and nitrogen metabolism. It showed that chloroplasts of land plants optimize photosynthesis with a transporter that exchanges potassium and hydrogen, and cyanobacteria with one that exchanges sodium and hydrogen.
*Illustrative imageEnvironmental Adaptation in Microorganisms
Using E. coli and yeast, the lab studies the fundamental mechanisms of living organisms. It works on how channels that sense mechanical stimuli transmit external changes into the cell, and on the switching mechanism by which bacteria form biofilms and survive when their growth environment deteriorates.
MembersFaculty
The members of the Uozumi Lab are faculty, research fellows, a visiting professor, research collaborators, and doctoral, master's, and undergraduate students.As of 2026
- ProfessorNobuyuki Uozumi
- Assistant ProfessorMasaru Tsujii
- Assistant ProfessorYuki Muraoka
- Project Assistant ProfessorEllen
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Two-pore domain potassium channel K2P2 PDB-4twk” Deposition authors: Pike, A.C.W., Dong, Y.Y., Tessitore, A., Goubin, S., Strain-Damerell, C., Mukhopadhyay, S., Kupinska, K., Wang, D., Chalk, R., Berridge, G., Grieben, M., Shrestha, L., Ang, J.H., Mackenzie, A., Quigley, A., Bushell, S.R., Shintre, C.A., Faust, B., Chu, A., Dong, L., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N.A., Carpenter, E.P.; Visualization author: Synpath / CC0 (cropped)
- Ion Transporters for Environmental Adaptation: “Arabidopsis thaliana kz07” Krzysztof Ziarnek, Kenraiz / CC BY-SA 4.0 (cropped)
- Developing Biostimulants: “Leaf epithelium, stomata and guard cells” Emilio Ermini / CC BY 4.0 (cropped)
- Response Mechanisms of Photosynthetic Organisms: “Bryum capillare leaf cells” Des_Callaghan / CC BY-SA 4.0 (cropped)
- Environmental Adaptation in Microorganisms: “E coli at 10000x, original” Photo by Eric Erbe, digital colorization by Christopher Pooley, both of USDA, ARS, EMU. / Public domain (cropped)
- Related lab (Takahashi Lab): “Lysozyme Protein Crystal in Hanging-Drop Crystallization” Rohit Sharma / CC BY 4.0 (cropped)
- Related lab (Aoki Lab): “Combustor-Temp-Plane” Atif Masood (FetchCFD) / CC BY 4.0 (cropped)
- Related lab (Tomai Lab): “Critical carbon dioxide-3” Bernhard Kuemel、Regi51 / CC BY-SA 2.0 at (cropped)
- Related lab (Oi Lab): “Hoveyda-Grubbs-catalyst-1st-gen 3D-balls” Diogo Duarte / CC BY-SA 3.0 (cropped)
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