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Pathological Nanosystems Biomedical Engineering Lab
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A lab that observes the movement of molecules to uncover the causes of lifestyle-related diseases.
AboutAbout the lab
Watching molecules move to explore how life works.
The Pathological Nanosystems Biomedical Engineering Lab uses new bioimaging technology to study how supramolecular complexes made of many molecules are regulated in time and space.
In particular, it aims to clarify the causes of "biological nanosystem disorders" that occur in lifestyle-related diseases such as type 2 diabetes and in diseases of higher-order nervous system function.
It also aims to apply the technology to the development of treatments and diagnostics from new perspectives.
The lab also works on creating higher-function cells using the latest cell engineering and genetic engineering.
Key terms
- Supramolecular complex
- A cohesive assembly formed by many molecules coming together
- Bioimaging
- A technique that captures the state of molecules inside living cells as images in order to study them
- GLUT4
- A glucose transporter that moves to the cell membrane in response to insulin or exercise and acts to lower blood glucose
ResearchResearch themes
The lab aims to elucidate "biological nanosystem disorders" that occur in lifestyle-related diseases and brain function diseases. Its research uses imaging technology that visualizes the movement of molecules inside living cells, and cell engineering such as cultured muscle cells that can exercise.
*Illustrative imageMolecular dynamics physiology: watching molecules move
The lab has established experimental systems that can observe and quantitatively evaluate how molecules move inside living cells at the single-molecule level. Applying them to GLUT4, the glucose transporter that lowers blood glucose, it investigates the mechanisms of intracellular trafficking.
*Illustrative imageDeveloping cultured muscle cells that can exercise
Using biomedical engineering methods, the lab has built a special culture system and succeeded in producing cultured muscle cells that contract actively. Exercise stimulation reproduces exercise effects such as improved insulin response, and the lab is investigating the molecular mechanisms behind them.
*Illustrative imageMolecular basis of lifestyle-related diseases and exercise effects
The lab studies how skeletal muscle, which is attracting attention as a therapeutic target for lifestyle-related diseases such as type 2 diabetes, produces beneficial effects in response to exercise stimulation. It hopes to expand this into pioneering new types of drug discovery and treatment technologies that target skeletal muscle.
*Illustrative imageEffects of plasma on living organisms
The lab aims to clarify the effects of plasma generated at atmospheric pressure and low temperature on biological tissue, as well as the reaction pathways involved. By irradiating skeletal muscle cells, it analyzes changes in intracellular signal transduction and metabolism, and it also works on improving and developing irradiation devices.
MembersFaculty
The lab's members consist of faculty, technical assistants, and doctoral, master's, and undergraduate students.As of 2026
- ProfessorMakoto Kanzaki
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Confocal Microscope (NIH BioArt 86)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Molecular dynamics physiology: watching molecules move: “SK8-18-2 human derived cells, fluorescence microscopy ( )” ZEISS Microscopy from Germany / CC BY 2.0 (cropped)
- Developing cultured muscle cells that can exercise: “Cell Culture in a tiny Petri dish (cropped)” kaibara87 / CC BY 2.0 (cropped)
- Molecular basis of lifestyle-related diseases and exercise effects: “Insulin Application” Mr Hyde at Czech Wikipedia (Original text: moje foto) / Public domain (cropped)
- Effects of plasma on living organisms: “Atmospheric-pressure plasma” Alibabble / CC0 (cropped)
- Related lab (Bioelectronics Lab): “Wafer - 3” Windell Oskay / CC BY 2.0 (cropped)
- Related lab (Future Electronics Foundation Creation [Kuroda] Lab): “FUGA 18 Retina” Mister rf / CC BY-SA 4.0 (cropped)
- Related lab (Medical Imaging Lab): “Pancreas ultrasound doppler” Ptrump16 / CC BY-SA 4.0 (cropped)
- Related lab (Electromagnetic Wave Engineering [Chen-Konno-Sato] Lab): “XEMU Antenna Testing in JSC's Anechoic Chamber (jsc2021e022488)” NASA Johnson Space Center / Norah Moran / Public domain (cropped)
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