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Tumor Biomedical Engineering [Kodama] Lab
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The lab uses nanotechnology to explore the mechanisms of lymph node metastasis and take on cancer treatment.
AboutAbout the lab
Clarifying the mechanism of lymph node metastasis.
The lab conducts research to clarify the mechanism of lymph node metastasis and to create new cancer therapies.
Using nanotechnology, it investigates how cancer spreads via the lymph nodes.
The lab has also developed “lymphatic drug delivery,” in which an anticancer drug is injected directly into a lymph node so that it reaches the downstream lymph nodes as well.
The lab is presented on its website under the name “Kodama Lab.”
Key terms
- Lymph node metastasis
- The process in which cancer cells travel through lymphatic vessels to lymph nodes and multiply there. It serves as an indicator of how the cancer will progress
- Lymphatic drug delivery
- A method of injecting an anticancer drug directly into a lymph node to deliver it to that node and the downstream lymph nodes
- Lymph node dissection
- Surgical removal of lymph nodes suspected of cancer metastasis, taken out together as a group
NewsLab news
Professor Kodama received the 19th Mizushima Award from the Japan Society of Drug Delivery System
An assistant professor received the Journal Award at the 42nd Annual Meeting of the Japan Society of Drug Delivery System
An assistant professor received the Japan Society of Lymphology Encouragement Award (Nishi Award) at the 50th General Meeting of the Japan Society of Lymphology
A paper by master's students and others was published in The Journal of Controlled Release, and a press release was issued
A paper by an assistant professor and others was published in The Journal of Pathology, and a press release was issued
ResearchResearch themes
Among cancer metastases, lymph node metastasis is an important clue to how the cancer will progress, but its mechanism remains unclear. This lab uses nanotechnology to study how lymph node metastasis occurs, aiming to lead to new cancer treatments.
*Illustrative imageTesting Hematogenous Metastasis via Lymph Nodes
Using nanotechnology, the lab experimentally tests the theory that metastasis passes through lymph nodes and enters the bloodstream. It has been shown that fluorescent particles injected into a mouse's tail vein flow from veins within the lymph node into the thoracoepigastric vein and exit into the subclavian vein.
*Illustrative imageDevelopment of Lymphatic Drug Delivery
This is the lab's own method, in which an anticancer drug is injected directly into a lymph node, aiming to treat metastatic cancer in that node and in the downstream lymph nodes. Because lymph flows in one direction, and fluorescent dye injected into an upstream lymph node flows downstream, treatment of downstream lymph nodes is expected.
*Illustrative imageActivation of Cancer Cells After Lymph Node Dissection
Clinical cases have been reported in which removing lymph nodes activates cancer cells locally or in distant organs. The lab aims to clarify this relationship using a lung-metastasis-activation mouse model it developed.
MembersFaculty
The lab's members consist of faculty, part-time lecturers, academic researchers, secretaries, doctoral, master's, and undergraduate students, and visiting researchers.As of 2026
- ProfessorTetsuya Kodama
- Assistant ProfessorAriunbuyan Sukhbaatar
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Scanning electron microscope - UFCH JH (2020) 04” Tadeáš Bednarz / CC BY-SA 4.0 (cropped)
- Testing Hematogenous Metastasis via Lymph Nodes: “Microscope à fluorescence (Ifremer )” Olivier Dugornay / CC BY 4.0 (cropped)
- Development of Lymphatic Drug Delivery: “Chemotherapy vials” Bill Branson (Photographer) / Public domain (cropped)
- Activation of Cancer Cells After Lymph Node Dissection: “Operating room” John Crawford (Photographer) / Public domain (cropped)
- Related lab (Solid-State Electronics Lab): “Wafer - 2” Windell Oskay / CC BY 2.0 (cropped)
- Related lab (Ubiquitous Energy Lab): “MSS1 CDSM flight model” A. Pollinger / CC BY 4.0 (cropped)
- Related lab (Yoshidome Lab): “HydrationLayer2New” Babusingh252 at en.wikipedia / Public domain (cropped)
- Related lab (Communication and Information Measurement [Matsuura] Lab): “Upconversion Fluorescence - Optical fiber that contains infrared light shines with a blue color in the dark - Laser Physics Lab - NTNU-NT” NTNU, Faculty of Natural Sciences and Technology / CC BY 2.0 (cropped)
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