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Mizutani-Kuji Lab
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The lab gives surfaces new functions through machining and applies this to medicine.
AboutAbout the lab
Machining technology for medical and biological applications.
The Mizutani-Kuji Lab studies machining technologies that create fine structures on material surfaces, and their application to medicine.
The lab develops machining methods that combine ultra-precision mechanical processes such as cutting and grinding with ultrasonic vibration or laser irradiation.
When laser irradiation changes the shape and composition of a surface, the way the surface interacts with cells and bacteria changes as well.
Focusing on this change, the lab is working to create bioimplants with surfaces that are "gentle to cells and strong against bacteria."
Key terms
- LIPSS
- Periodic fine structures (laser-induced periodic surface structures) that form on a material surface through self-organization when an ultrashort-pulse laser is applied under specific conditions
- Bioimplant
- A medical component used inside the body, which must be compatible with living tissue and cells
- Powder jet machining
- A jet-based process that hits a material with fine particles at high speed to remove material or, conversely, to make the particles adhere
NewsLab news
A student received the Best Paper Award at nanoMan / ICMTE 2026
A student received an Outstanding Presentation Award at the student research exchange meeting of the Biomaterials and Medical Materials Division Committee of the Society of Materials Science, Japan
A research fellow received a Best Presentation Award at CJUMP2025
ResearchResearch themes
The lab aims to create new functions by forming fine structures, from the nanometer to the micrometer scale, on material surfaces. It develops methods that combine mechanical machining with laser irradiation, and its research ranges from machining molds used to form optical elements to medical implants and dental treatment.
*Illustrative imageSurfaces combining nano- and micro-scale structures
The lab creates multiscale 3D hybrid structures in which nanometer-scale structures are layered on top of micrometer-scale structures. It has developed an ultrasonic spindle that vibrates along three axes and combines it with ultra-precision cutting and grinding, working to produce these structures efficiently over large areas.
*Illustrative imageCutting while applying a laser
When molds with fine structures are made by ultra-precision cutting, burrs and chipping from the submicrometer to micrometer scale occur and reduce shape accuracy. By using laser irradiation to locally heat the region where the chip forms and change the properties of the material, the lab aims to achieve machining with fewer defects.
*Illustrative imagePeriodic fine structures produced by lasers
When an ultrashort-pulse laser with a picosecond to femtosecond pulse width is applied under specific conditions, periodic fine structures (LIPSS) form on the material surface through self-organization. The lab investigates the mechanism through both experiments and analysis, aiming for practical use of functions such as wettability, optical functions, and lubricity.
*Illustrative imageDental treatment by spraying particles
Powder jet machining can switch between machining that removes material by hitting it with fine particles at high speed and machining that makes particles adhere, simply by changing the conditions. Because it works at room temperature and atmospheric pressure, the lab is working on developing a dental treatment method that builds new tooth structure.
MembersFaculty
The members of the Mizutani-Kuji Lab are faculty, a visiting associate professor, part-time lecturers, research fellows, secretaries, doctoral, master's, and undergraduate students, and short-term exchange students.As of 2026
- ProfessorMasayoshi Mizutani
- Assistant ProfessorChieko Kuji
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Dr. Vitalii Mocharskyi during experiments on laser processing” Vitterok / CC BY 4.0 (cropped)
- Surfaces combining nano- and micro-scale structures: “Root analogue ceramic dental implant vs titanium screw type implant” Logicwhatelse / CC BY-SA 4.0 (cropped)
- Cutting while applying a laser: “Laserkop van Amada FO-4020NT 4kW, industriële laser” Contour / CC0 (cropped)
- Periodic fine structures produced by lasers: “Femtosecond laser” Mina.ashrafzade / CC BY-SA 4.0 (cropped)
- Dental treatment by spraying particles: “Dental instruments J1” Jamain / CC BY-SA 3.0 (cropped)
- Related lab (Hayashibe-Zhu Lab): “Cronos humanoid robot” Science Swiss @ Singapore / CC BY-SA 3.0 (cropped)
- Related lab (Owaki Lab): “NCATS Robots ( )” National Center for Advancing Translational Sciences from Bethesda, MD / Public domain (cropped)
- Related lab (Murata-Abe Lab): “Molecular Machines of Life” 作者不詳 / Public domain (cropped)
- Related lab (Nomura (S.)-Matsubayashi Lab): “Sarfus.LipidVesicles” Nanolane / Public domain (cropped)
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