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Ohta Lab
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A lab that does engineering useful for treatment, using blood vessel models and cell experiments.
AboutAbout the lab
Engineering that confronts disease and serves treatment.
The Ohta Lab aims to develop medical devices useful for treatment and to establish new therapies.
The lab works on biomodels that reproduce the shape and properties of biological tissue, and on methods for making them.
Using polyvinyl alcohol hydrogel, the lab was the first in the world to develop a blood vessel model that reproduces the mechanical properties of blood vessels.
The lab pursues joint development with medical sites, medical device manufacturers, and a venture company established by the lab, and also accepts international students and exchanges with overseas universities.
Key terms
- Biomodel
- A model that reproduces the shape and mechanical properties of biological tissue using polymer materials and the like
- Stent
- A tube-shaped mesh placed inside a blood vessel. It is used in treatments that widen vessels or change blood flow
- Endothelial Cell
- Cells that line the innermost surface of blood vessels. They are involved in how easily a vessel becomes blocked
ResearchResearch themes
As engineering that confronts disease, the lab aims to develop devices useful for treatment and to establish new therapies. It develops blood vessel biomodels for practicing procedures and developing medical devices, and elucidates the mechanisms of lesion formation through experiments that apply stimuli such as flow to cultured cells.
*Illustrative image3D Printer for Blood Vessel Models
If a model with each patient's own anatomy can be made quickly, the procedure can be checked just before surgery. The lab is developing a PVA-H (polyvinyl alcohol hydrogel) 3D printer for this purpose, and in addition to engineering tests, it conducts sensory evaluation by physicians.
*Illustrative imageBlood Vessel Models Visible under Ultrasound
A model used to evaluate ultrasound imaging systems must have not only a shape and mechanical properties close to those of living tissue, but also ultrasound images close to those of living tissue. The lab is developing a model that contains scatterers while also being transparent enough for catheters to be seen.
*Illustrative imageStent Endothelialization and Flow
When endothelial cells cover a stent placed in a blood vessel, it may prevent the vessel from becoming blocked again. Using cell experiments and fluid simulation, the lab investigates how differences in flow due to stent shape and differences in surface treatment affect endothelialization.
MembersFaculty
- ProfessorMakoto Ohta
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Cobalt Chromium Coronary Stent in Heart” ETTon / CC BY-SA 4.0 (cropped)
- 3D Printer for Blood Vessel Models: “3D printing functional prototypes” Svitlana Lozova / CC BY-SA 4.0 (cropped)
- Blood Vessel Models Visible under Ultrasound: “Abdominal Ultrasound Imaging in Navi Mumbai” Goleisureintl / CC BY 4.0 (cropped)
- Stent Endothelialization and Flow: “Taxus stent FDA” Food and Drug Administration / Public domain (cropped)
- Related lab (安西 研究室): “Incompressible Flow in a Venturi Injector” SimScale GmbH / CC BY-SA 4.0 (cropped)
- Related lab (石川 研究室): “Blood Vessel (NIH BioArt 55)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab
(菊地 研究室): “Titan models red blood cells ( )” Oak Ridge National Laboratory / CC BY 2.0 (cropped) - Related lab (大森 研究室): “Cardiovascular system - Blood flow 1 -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
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