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Applied Molecular Imaging Science Lab
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A lab that creates "molecular probes" that visualize the workings of molecules inside the body.
AboutAbout the lab
Seeing molecules in images to connect diagnosis and treatment
The Applied Molecular Imaging Science Lab researches and develops new molecular probes for molecular imaging, which turns information about molecules inside the body into images.
Its work spans searching for target molecules, techniques for designing and synthesizing probes, developing synthesis equipment, and research toward clinical use.
Recently, the lab has put particular effort into research on precision medicine and theranostics, which link image-based diagnosis to accurate treatment.
The staff come from varied fields such as pharmaceutical sciences, veterinary medicine, and agriculture, and the lab recruits graduate students regardless of their undergraduate faculty or university.
Key terms
- Molecular probe
- A substance that converts information about molecules inside the body into signals that instruments can measure
- Theranostics
- An approach that combines diagnosis (imaging) and treatment by using drugs that target the same molecule
- Molecular imaging
- A technology that visualizes, from outside the body, where and how specific molecules are working inside the body
ResearchResearch themes
The lab studies new molecular probes for molecular imaging (diagnostic imaging) and treatment. It searches for target molecules useful for evaluating disease states and determining treatment effects, and carries out work from probe design and synthesis through to clinical translation.
*Illustrative imageMolecular imaging for personalized cancer medicine
To examine the malignancy of cancer and the efficacy of drugs from outside the body, the lab develops imaging agents that target enzymes active in tumors and molecules abundant in cancer cells. Using multivalent peptides with multiple binding moieties, it also looks ahead to Radiotheranostics, which integrates nuclear medicine diagnosis and treatment.
*Illustrative imageDiagnosing steatohepatitis with imaging
The lab aims for a nuclear medicine diagnostic method that can examine the whole liver at once, as an alternative to liver biopsy, which is painful and gives variable results. In an animal model, it identified an enzyme that serves as a marker of steatohepatitis (NASH) and showed that diagnosis may be possible by SPECT/CT imaging with an imaging agent that targets that enzyme.
MembersFaculty
The lab members consist of faculty, doctoral students, and research students.As of 2025
- ProfessorYuji Kuge
- Assistant ProfessorYuki Mizuno
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Molecubes SPECT uCT and PET (cropped)” Adville / CC BY-SA 4.0 (cropped)
- Molecular imaging for personalized cancer medicine: “Radioactive Syringe and Shield” Thirteen Of Clubs from Minneapolis / CC BY-SA 2.0 (cropped)
- Diagnosing steatohepatitis with imaging: “SPECT CT OPTIMA GE 642CMH” Nightryder84 / CC BY-SA 3.0 (cropped)
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