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Marine Biotechnology Lab
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A lab that uncovers the molecular structures of marine organisms using cryo-electron microscopy.

AboutAbout the lab
Seeing the shapes of molecules directly under a microscope
Associate Professor Takeshi Yokoyama uses cryo-electron microscopy to determine the structures of biomolecules derived from marine organisms.
Cryo-electron microscopy is a method in which biomolecules are rapidly frozen, trapped in a thin film of glass-like ice, and observed directly with a transmission electron microscope.
The lab focuses on ribosome complexes and works on the structural analysis of a variety of biomacromolecular complexes.
Samples are prepared in the lab, data are collected at cryo-electron microscopy facilities across Japan, and structural analysis and biochemical functional analysis are then carried out in the lab.
Key terms
- Cryo-electron microscopy
- A method of imaging rapidly frozen biomolecules with an electron microscope to determine their three-dimensional structure
- Ribosome
- A particle in the cell that makes proteins based on genetic information
- Translational regulation
- The mechanisms by which a cell regulates the process of making proteins from genetic information (translation)
ResearchResearch themes
The lab uses cryo-electron microscopy to determine the structures of biomolecules derived from marine organisms. It focuses on ribosome complexes and works on the structural analysis of a variety of biomacromolecular complexes.
*Illustrative imageHow antibiotics act on the ribosome
The lab aims to use cryo-electron microscopy to reveal how new antibiotics that are effective against multidrug-resistant bacteria act on the ribosome.
*Illustrative imageRibosomes of marine organisms
Focusing on the ribosomes of marine organisms, the lab aims to elucidate the mechanisms of translational regulation (the regulation of the process of making proteins) and to develop applications based on them.
MembersFaculty
- Associate ProfessorTakeshi Yokoyama
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Ribosome shape” Vossman / CC BY-SA 3.0 (cropped)
- How antibiotics act on the ribosome: “Streptomyces hygroscopicus” Snuupo / CC BY-SA 4.0 (cropped)
- Ribosomes of marine organisms: “Halocynthia roretzi Uminomori” Totti / CC BY-SA 4.0 (cropped)
- Related lab (Marine Bioengineering Lab (Prof. Akira Inoue)): “Aplysia kurodai” Izuzuki Diver / CC BY-SA 2.5 (cropped)
- Related lab (Marine Microbiology Lab (Marine Bioengineering Division)): “Vibrio parahaemolyticus TCBS” Matthias M. / CC BY-SA 4.0 (cropped)
- Related lab (Marine Biotechnology Lab): “Moon jellyfish at Gota Sagher” Alexander Vasenin / CC BY-SA 3.0 (cropped)
- Related lab (Developmental Biology Lab (Breeding Biology Lab)): “Dojo loach4” Gourami Watcher / CC BY 3.0 (cropped)
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