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Human Information Engineering Lab
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A lab that develops technologies for seeing inside the body and treating it using light and ultrasound.
AboutAbout the lab
Contributing to medicine with light and ultrasound
The Human Information Engineering Lab researches and develops engineering technologies aimed at contributing to medicine.
The lab works on applied technologies using light and ultrasound that help advance diagnosis and treatment.
The Photonics group develops diagnostic technologies using light, while the Ultrasound group develops diagnostic technologies using ultrasound and cell-level treatment technologies using microbubbles.
Staff with backgrounds in biomedical engineering, optics, spectroscopy, and electronics, information, and communication engineering work together to advance research and education in an interdisciplinary way.
Key terms
- Nonlinear Raman scattering
- A phenomenon that captures molecular vibrations by applying intense light. It can be observed faster than weak spontaneous Raman scattering
- Ultrashort-pulse laser
- A laser that emits light only for an extremely short time, such as picoseconds. It is used to capture molecular vibrations
- Microbubble
- A tiny bubble about one-thousandth of a millimeter in diameter. It is injected into blood vessels and exposed to ultrasound for use in diagnosis and treatment
NewsLab news
View More ↗ResearchResearch themes
The lab conducts research and education that apply information science and engineering to the human being as a living whole. Aiming to contribute directly to medicine, the Photonics group, which uses light, and the Ultrasound group, which uses ultrasound, are developing diagnostic and treatment technologies.
*Illustrative imageDistinguishing lesions by molecular vibrations
In pathological diagnosis, tissues and cells that are almost colorless are stained for observation, but staining affects living cells and takes time. Using the fact that the frequency of molecular vibrations varies with the type and structure of the molecule, the lab is developing imaging devices that can distinguish tissue and lesions without staining, and applying them to diagnosis.
*Illustrative imageDeveloping synchronized ultrashort-pulse lasers
Nonlinear Raman scattering imaging requires a special light source that simultaneously delivers two laser pulses of different wavelengths, each with a narrow spectral width and a picosecond duration. The lab is developing its own light source in which the wavelength of one pulse can be changed rapidly, aiming to realize stain-free imaging that can be used in clinical settings.
*Illustrative imageDiagnosis and treatment with microbubbles
By injecting nano- or micron-sized microbubbles into blood vessels and applying ultrasound, tiny lesions that could not be seen before can be detected. If the bubbles are used as containers to carry drugs or genes, this can also lead to treatment of lesions deep in the body.
*Illustrative imageUltra-high-speed imaging of microbubble motion
Bubbles that receive ultrasound repeatedly expand and contract, and are thought to focus the energy they receive onto a single point. The lab observes bubble oscillation at up to 20 million frames per second to investigate how this works.
MembersFaculty
The members of the Human Information Engineering Lab consist of faculty, research fellows, secretaries, and master's and undergraduate students.As of 2026
- ProfessorMamoru Hashimoto
- Assistant ProfessorYuji Kato
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Femtosecond Laser and Pulse Compressor - Optics Lab - INRIM” Giorgio Brida from Torino, Italy / CC BY 2.0 (cropped)
- Distinguishing lesions by molecular vibrations: “Endometrium and adipose tissue -- high mag” Nephron / CC BY-SA 3.0 (cropped)
- Developing synchronized ultrashort-pulse lasers: “Dispersion of White Light Through a Prism” Aligatorigiganti / CC0 (cropped)
- Diagnosis and treatment with microbubbles: “Water bubbles in a fish tank within the nature center at the Watershed Institute in Hopewell Township, Mercer County, New Jersey” Famartin / CC BY-SA 4.0 (cropped)
- Ultra-high-speed imaging of microbubble motion: “Antibubble cluster” TheAlphaWolf / CC BY 3.0 (cropped)
- Related lab (Integrated Nanosystems Lab): “Нейрон коры с множеством дендритных шипиков” Sergb95 / CC BY-SA 4.0 (cropped)
- Related lab (Coherent Light Lab): “SACLA Undulator” SRIA / CC BY-SA 4.0 (cropped)
- Related lab (Organic Quantum Photonic Devices Lab): “« Batteries et innovation » Laboratoire de Physique de la Matière Condensée Laboratoire de Physique des Interfaces et Couches Minces Thématique « Innovation et applications industrielles » ( )” Ecole polytechnique Université Paris-Saclay / CC BY-SA 2.0 (cropped)
- Related lab (Cell Bioengineering Lab): “Fibroblastid (BPAE)” Heiti Paves / CC BY-SA 3.0 (cropped)
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