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Microsystem Chemistry Lab
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The lab builds technologies for measurement and diagnosis on tiny chips.
AboutAbout the lab
Measurement technologies born from unique ideas that surprise the world.
The Microsystem Chemistry Lab develops bioanalytical and medical diagnostic technologies based on new measurement techniques.
Carrying out chemistry experiments on a very small scale requires less sample and fewer reagents, and makes possible experiments that are difficult in a flask.
The lab works on diagnosis from a single drop of blood, on-site testing in the field, and analysis that combines paper devices with smartphones.
Its devices are also used to make the lipid nanoparticles used in vaccines and to analyze the three-dimensional structures of proteins, which underpin drug discovery.
Key terms
- Microfluidic device
- A small plate with channels as thin as a hair etched into it. Small amounts of liquid flow through it for reactions and analysis
- Immunoassay
- A method that measures the amount of a target component by using the property of antibodies binding only to a specific substance
- Lipid nanoparticle
- A nanometer-sized particle made of lipids. It encloses drugs such as nucleic acids and delivers them into the body
NewsLab news
Professor Maeki's explanatory article on exosomes published in Cosmetic Science
Results of joint research with the Institute of Medical Science, the University of Tokyo, published in Nature Biotechnology
A doctoral student received the Excellent Poster Award at an international symposium
Results of joint research with Osaka University published in Angewandte Chemie International Edition
ResearchResearch themes
By moving beaker and flask experiments onto a small chip, the lab achieves analysis that is micro-scale, rapid, and simple. It develops microsystems that meet social needs, from medical diagnosis to environmental analysis and drug discovery.
*Illustrative imageMicrochips Integrating Diagnostic Functions
Together with Nagoya University Hospital and others, the lab develops immunoassay chips that can diagnose disease from a single drop of blood, as well as chips that measure drug concentrations in the blood.
*Illustrative imageAnalytical Instruments for On-Site Use
The lab has fundamentally miniaturized high-performance liquid chromatography (HPLC) instruments, developing analytical instruments that can run on batteries and be used at sites where testing is needed.
*Illustrative imageDevices for Making Lipid Nanoparticles
The size of lipid nanoparticles greatly affects how they move in the body and how efficiently they deliver nucleic acids. Together with the Faculty of Pharmaceutical Sciences at Hokkaido University, the lab is developing microfluidic devices that can precisely control particle size, aiming for practical use.
*Illustrative imageDevices for Examining Protein Shapes
The three-dimensional structure of a protein is essential for drug discovery and for understanding its function. The lab develops microfluidic devices that can analyze the structures of proteins, and of complexes bound to other molecules, with small amounts of sample, simply, and quickly.
MembersFaculty
The members of the Microsystem Chemistry Lab consist of faculty, researchers, administrative staff, and doctoral, master's, and undergraduate students.As of 2026
- ProfessorManabu Tokeshi
- ProfessorMasatoshi Maeki
- Assistant ProfessorAkihiko Ishida
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Microfluidic chip for point-of-care medical devices” FMNLab / CC BY 4.0 (cropped)
- Microchips Integrating Diagnostic Functions: “Lab on a Chip ( )” National Institute of Standards and Technology / Public domain (cropped)
- Analytical Instruments for On-Site Use: “Early prototype” Ciccioformaccio / CC BY-SA 4.0 (cropped)
- Devices for Making Lipid Nanoparticles: “Phosphatidylcholine liposomes at phase-contrast microscopy” ArkhipovSergey / CC BY-SA 4.0 (cropped)
- Devices for Examining Protein Shapes: “Lysozyme Crystals in Hanging-Drop Formation” Rohit Sharma / CC BY 4.0 (cropped)
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- Related lab (Biomolecular Chemistry Lab): “Microbial cellulose pellicle” User:Lightenoughtotravel / Public domain (cropped)
- Related lab (Materials Chemical Engineering Lab): “Activated-charcoal-i” Mubychemcom / CC0 (cropped)
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