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Seki Lab (Medical Information Data Science)
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The lab develops methods to measure gene activity using sequencing technology.
AboutAbout the lab
Opening up omics analysis built on sequencing
The Seki Lab develops sequencing-based omics analysis methods, along with methods for analyzing the resulting data.
Genes are regulated at many levels, including the genome, epigenome, and transcriptome, before they function as proteins.
Working mainly with humans and mice, the lab aims to clarify how this regulation of gene function works.
Using the methods it has developed, along with approaches such as single-cell analysis, the lab also studies a range of diseases, including cancer.
Key terms
- Transcriptome
- The entire set of RNA being read out in a cell. It shows which genes are active and to what extent.
- Epigenome
- Information carried by chemical marks attached to DNA and histones, separate from the DNA sequence itself. It determines how genes are used.
- Splicing
- The process of cutting out parts of the RNA read from a gene and joining the remaining pieces together. It allows different RNAs to be made from the same gene.
NewsLab news
Research group develops a method to analyze methylation of long DNA stretches in targeted regions from small cancer specimens
Research group develops TSS-seq2, a method for detecting gene transcription start sites
ResearchResearch themes
Building on next-generation sequencing, long-read sequencing, and related technologies, the lab develops omics analysis methods and data analysis methods. It aims to clarify how gene function is regulated, and also applies the methods it has developed to disease research.
*Illustrative imageReading DNA methylation with long-read sequencing
By combining base conversion with nanopore sequencing, the lab has developed a method that can read methylation patterns on individual molecules, even from small amounts of DNA. It applies this method to normal tissue and cancer specimens.
*Illustrative imageDeveloping and applying transcriptome analysis
Using long-read sequencers to read full-length messenger RNA, the lab searches for splicing specific to particular tissues and diseases. It also develops methods to measure how RNA is produced and degraded.
MembersFaculty
- Project Associate ProfessorMasahide SekiPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Micropipette Rack” Alyssa LaGrange / CC BY 4.0 (cropped)
- Reading DNA methylation with long-read sequencing: “Nanopore Sequencing ( )” National Human Genome Research Institute (NHGRI) from Bethesda, MD, USA / CC BY 2.0 (cropped)
- Developing and applying transcriptome analysis: “Gel Electrophoresis” Nik.vuk / CC BY-SA 4.0 (cropped)
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