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Noda Lab (Biofunctional Molecular Engineering Division, National Institute of Advanced Industrial Science and Technology)
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A lab that develops technologies to measure DNA and proteins accurately and works to turn them into standards.
AboutAbout the lab
Measuring biomolecules, from practical use to standardization.
The Noda Lab studies the development and application of new technologies for analyzing biomolecules such as nucleic acids and proteins.
The lab's research takes place at the National Institute of Advanced Industrial Science and Technology (AIST).
The lab aims to put the technologies it develops into practical use in collaboration with companies, and also seeks to apply them to developing nucleic acid reference materials and to international standardization.
The environment allows a wide range of activities, from research and development to commercialization through collaboration with companies and international standardization.
Key terms
- Reference material
- A substance with a precisely defined quantity or concentration, used to verify that measurements are correct. It serves as a "ruler" for measuring instruments.
- Digital PCR
- A method that divides a sample into many tiny partitions, amplifies the DNA in each, and counts the partitions where amplification occurred, thereby directly counting the number of DNA molecules.
- Nucleic acid
- DNA and RNA. Biomolecules that carry genetic information.
ResearchResearch themes
The lab develops new technologies for analyzing biomolecules such as nucleic acids and proteins, and advances their applications. It works on developing nucleic acid reference materials used in clinical testing, and on building a foundation for drug discovery targeting enzymes related to nucleic acids.
*Illustrative imageNucleic Acid Reference Materials and Standardization of Measurement
The lab develops nucleic acid reference materials used to verify that clinical testing instruments are measuring correctly. It adopts methods that directly count the number of molecules, such as fluorescence correlation spectroscopy and digital PCR, and is also advancing international standardization through ISO and other bodies.
*Illustrative imageDrug Discovery Screening for Nucleic Acid-Related Enzymes
The lab develops techniques for examining the activity of enzymes involved in DNA and RNA replication, cleavage, and repair. It focuses in particular on the Toxin-Antitoxin system, which is responsible for programmed cell death in microorganisms, and searches for molecules that control it.
MembersFaculty
- Visiting ProfessorNaohiro Noda
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “96 well PCR plate-01” Lilly_M / CC BY-SA 3.0 (cropped)
- Nucleic Acid Reference Materials and Standardization of Measurement: “PCR tubes” Madprime / CC0 (cropped)
- Drug Discovery Screening for Nucleic Acid-Related Enzymes: “E coli at 10000x, original” Photo by Eric Erbe, digital colorization by Christopher Pooley, both of USDA, ARS, EMU. / Public domain (cropped)
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