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Iwasaki Lab (RNA Systems Biology Department, RIKEN)
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The lab investigates how translation, the process by which proteins are made from RNA, is regulated.
AboutAbout the lab
How RNA translation governs life
The Iwasaki Lab studies how translation, the reaction in which proteins are made from RNA, is regulated.
RNA was long thought to be merely a messenger carrying the information for proteins, but it has become clear that the amount and quality of protein produced from an RNA cannot be simply predicted.
The lab aims to clarify which RNAs are regulated and how, and how this regulation governs life.
It combines two approaches: comprehensive analysis using next-generation sequencers and classical biochemistry.
Key terms
- Translation
- The reaction in which ribosomes link amino acids together to make proteins, based on the information written in RNA
- Next-generation sequencer
- An instrument that reads large numbers of DNA or RNA sequences at once
- Ribosome profiling
- A technique that comprehensively examines where on RNAs ribosomes are reading, to survey the state of translation
ResearchResearch themes
Of the central dogma, "DNA makes RNA, and RNA makes protein," the lab studies how translation, the step in which proteins are made from RNA, is regulated and how it controls life. By combining two main methodologies, the lab takes on the mysteries of the biological phenomena governed by RNA and its translation.
*Illustrative imageSurveying translation with next-generation sequencers
Using a technique called ribosome profiling, the lab comprehensively examines which codons of which RNAs are being read by ribosomes, giving a broad view of the state of translation. It also investigates which RNAs the RNA-binding proteins that regulate translation bind to, and clarifies the relationships among the three: RNAs, ribosomes, and RNA-binding proteins.
*Illustrative imageUncovering the mechanisms of translation through biochemistry
Translation is a complex reaction that proceeds through many steps, each with its own regulatory mechanisms. Using classical yet powerful biochemical methods that break the reaction down and examine it process by process, the lab is uncovering the detailed mechanisms by which RNA and translation are regulated.
MembersFaculty
The members of the Iwasaki Lab consist of faculty, researchers and Special Postdoctoral Researchers, doctoral and master's students, technicians, and assistants.
- Visiting Associate ProfessorShintaro Iwasaki
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Crowded cytosol” TimVickers / Public domain (cropped)
- Surveying translation with next-generation sequencers: “DNA sequence” MIKI Yoshihito from Sapporo City,Hokkaido., JAPAN / CC BY 2.0 (cropped)
- Uncovering the mechanisms of translation through biochemistry: “Gel Electrophoresis” Nik.vuk / CC BY-SA 4.0 (cropped)
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