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Yamashita Lab (Division of Cancer Medical Informatics, National Cancer Center Japan)
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A lab that uses information science to interpret large-scale medical data on cancer.
AboutAbout the lab
Understanding cancer through data
The Yamashita Lab studies cancer using the medical and biological data gathered at the National Cancer Center Japan.
From multilayered data such as genomes and RNA, the lab searches for clues to how cancers arise and how they can be treated.
The lab uses bioinformatics methods to organize large volumes of data and extract information from them.
The lab is based at the Exploratory Oncology Research and Clinical Trial Center of the National Cancer Center Japan, next to the University of Tokyo's Kashiwa Campus.
Key terms
- Bioinformatics
- A field that uses computers and information science to organize and analyze large-scale biological and medical data
- Multi-omics analysis
- Analysis that combines comprehensive datasets of different types, such as genes, RNA, and metabolites
- Transcription start site
- The position where the process of copying DNA information into RNA (transcription) begins
NewsLab news
View More ↗ResearchResearch themes
Making full use of the clinical and multi-layered omics data gathered at the National Cancer Center Japan, the lab combines medicine, biology, and informatics to aim for new discoveries that will help cancer research. To integrate data and derive new knowledge, the lab develops and applies bioinformatics methods.
*Illustrative imageIntegrative Analysis of Big Medical Data
The lab performs multi-omics analysis that combines information such as genomes, transcriptomes, metabolomes, and metagenomes. By using correlation detection on supercomputers and AI-based pattern classification, it aims to extract new medical and biological information.
*Illustrative imageApproaching Cancer Through the Regulation of Transcription and Translation
The lab has built DBTSS/DBKERO, databases that represent accurate transcription start sites, RNA structures, and histone modifications, and has collected RNA data from normal cells and cancer cells. By combining these with public data to organize how RNA behaves, the lab aims to understand cancer through the regulation of transcription and translation.
MembersFaculty
The members of the Yamashita Lab are Division Chiefs and Unit Chiefs, researchers, physician-scientists, affiliated graduate students (doctoral and master's programs), and visiting researchers.
- Visiting Associate ProfessorRiu Yamashita
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images.
- Top image: “RNA Polymerase” Maria Voigt and PDB-101. This image is available under CC-BY-4.0 license. Attribution should be given to PDB-101 and Maria Voigt. / CC BY 4.0 (cropped)
- Integrative Analysis of Big Medical Data: “Heatmap” Miguel Andrade at English Wikipedia / Public domain (cropped)
- Approaching Cancer Through the Regulation of Transcription and Translation: “Gene Chip (NIH BioArt 669)” NIH NIAID Ryan Kissinger / Public domain (cropped)
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