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Goyama Lab (Advanced Molecular Oncology)
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The lab develops new treatments to cure blood cancers such as leukemia.
AboutAbout the lab
Uncovering how cancer develops to lead to drug discovery
The Goyama Lab studies the mechanisms of cancer pathophysiology and new treatments, focusing on hematologic malignancies such as leukemia.
With "curing cancer" as a realistic goal, the lab is developing treatments that use a variety of cutting-edge technologies and the power of the immune system.
The lab also conducts research to clarify how blood cells affect the progression of solid tumors and cardiovascular diseases, and to apply the findings to treatment and prevention.
Key terms
- Hematologic malignancy
- Cancer that arises from blood-forming cells, such as leukemia and lymphoma
- Cancer stem cell
- A cell that gives rise to cancer. It is thought to be the root of cancer onset and relapse
- lncRNA
- A long RNA that does not serve as a blueprint for proteins, also called long non-coding RNA. The functions of many are still unknown
NewsLab news
Review article on NPM1-r AML published in International Journal of Hematology
Paper from the lab published in Leukemia
Paper from the lab published in Experimental Hematology
A doctoral student received the Abstract Achievement Award at the ASH Annual Meeting
Paper from the lab published in BBRC
ResearchResearch themes
The lab analyzes the pathophysiology of cancer, focusing on hematologic malignancies, and develops new treatments. It is running three projects: drugs targeting transcription factors, cancer stem cells and tumor immunity, and lncRNA.
*Illustrative imageDrugs Targeting Transcription Factors
For transcription factors that lack good targeted drugs, the lab is working on protein degraders that promote degradation of the target molecule, and on nucleic acid medicines that deliver siRNA to leukemia cells using lipid nanoparticles (LNPs) co-developed with Toshiba's Corporate Research & Development Center.
*Illustrative imageCancer Stem Cells and Tumor Immunity
The lab found that leukemia stem cells resist treatment by evading attack from tumor immunity. It is now using in vivo CRISPR library screening to search for factors in cancer stem cells that suppress tumor immunity.
*Illustrative imageRoles of lncRNA and Targeted Drugs
The lab showed the importance of paraspeckles in hematopoietic stem cells and myeloid neoplasms. It is investigating the roles of lncRNAs in hematologic malignancies and developing nucleic acid medicines that target lncRNAs, including NEAT1.
MembersFaculty
- ProfessorSusumu GoyamaPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Acute Promyelocytic Leukemia, Marrow Aspirate ( )” Ed Uthman from Houston, TX, USA / CC BY 2.0 (cropped)
- Drugs Targeting Transcription Factors: “Mouse GABP ALPHA and BETA domain bound to DNA - DNA 1AWC” Batchelor AH, Piper DE, de la Brousse FC, McKnight SL, Wolberger C / CC0 (cropped)
- Cancer Stem Cells and Tumor Immunity: “T Lymphocyte ( )” NIAID / CC BY 2.0 (cropped)
- Roles of lncRNA and Targeted Drugs: “Multicolor fluorescence image of living HeLa cells” 8x57is / CC BY-SA 4.0 (cropped)
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