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Tomita Lab (Department of Molecularly Targeted Cancer Therapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research)
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A drug discovery lab targeting the mechanisms that let cancer cells survive harsh environments.
AboutAbout the lab
Curing cancer with drugs.
The Tomita Lab focuses on the growth environment inside the body that is characteristic of cancer (the tumor microenvironment), and studies molecularly targeted therapies that target the tumor microenvironment.
To survive in harsh environments lacking oxygen and nutrients, cancer cells adapt to environmental stress through mechanisms different from those of normal cells.
The lab investigates these adaptation mechanisms using gene expression analysis and bioinformatics.
The lab is located in the Division of Genome Research at the Cancer Chemotherapy Center of the Japanese Foundation for Cancer Research, and is a collaborative chair of the Graduate School of Frontier Sciences.
Key terms
- Tumor microenvironment
- The environment inside the body surrounding cancer cells. Inside a tumor, oxygen and nutrients tend to be in short supply.
- Molecularly targeted drug
- A drug that targets only specific molecules involved in cancer and suppresses their function.
- Bioinformatics
- The field of analyzing large amounts of biological data, such as genes, by computer.
ResearchResearch themes
The lab conducts research on molecularly targeted cancer therapy, centered on gene expression analysis and making use of bioinformatics. Its work rests on two pillars: "research on molecularly targeted therapies selective for the tumor microenvironment" and "genomics research on molecularly targeted therapy based on gene expression."
*Illustrative imageTherapies Targeting the Tumor Microenvironment
The lab investigates how cancer cells adapt to microenvironmental stresses such as hypoxia and glucose starvation. It aims to search for and develop new molecularly targeted drugs that control this adaptive response and selectively kill cancer cells.
*Illustrative imageGenomics Research Based on Gene Expression
Using information on gene mutations and gene expression in cancer cells and clinical specimens, the lab works on methods to diagnose whether molecularly targeted drugs will be effective, and on identifying new therapeutic targets that enhance treatment effects.
MembersFaculty
- Visiting ProfessorAkihiro Tomita
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images.
- Top image: “Cancer cells growing in media containing Blebbistatin” Nevena Morel, with my team Lisa Bourne and Nicolas Jacquemin / CC BY 4.0 (cropped)
- Therapies Targeting the Tumor Microenvironment: “Mus musculus melanoma skin cancer cells in UFV” Mateus Figueiredo / CC BY 4.0 (cropped)
- Genomics Research Based on Gene Expression: “Gene Chip (NIH BioArt 669)” NIH NIAID Ryan Kissinger / Public domain (cropped)
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