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Kikuchi Lab
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The lab reads the genomes of nematodes and parasites to uncover unknown biological phenomena.
AboutAbout the lab
Exploring the unknown sides of nematodes and parasites
Kikuchi Lab studies the still-unknown properties of a wide range of nematodes and parasites.
Omics analysis centered on genomics, together with computational data analysis, forms the core of its research.
Alongside understanding biological phenomena from the ground up, the lab aims to contribute to overcoming diseases caused by parasites.
Key terms
- Omics analysis
- A method of measuring and examining genes, proteins, and other molecules comprehensively all at once, rather than one at a time
- Chromosome diminution
- A phenomenon in which, in some cells of the body, part of the chromosomes is lost in a defined way
- Transposon
- A DNA sequence that can move around within the genome or increase its number of copies
NewsLab news
Published a paper on the response by which blood cells distinguish nematodes from non-living foreign objects
A master's student received the Department of Integrated Biosciences IB Award (Best Master's Thesis Award)
A master's student received the Best Presentation Award at the Annual Meeting of the Japanese Society for Immunology
Published a paper comparing the behavior of C. inopinata with that of C. elegans
Published a paper reporting the chromosome-level genome of Sparganum proliferum
ResearchResearch themes
Using omics analysis centered on genomics together with computational data analysis, the lab explores unknown aspects of diverse nematodes and parasites. Several projects are currently underway, including work on chromosome diminution and the mechanisms of parasitism.
*Illustrative imageMechanisms of chromosome diminution
In some organisms, programmed chromosome diminution occurs, in which part of the chromosomes is cut away in specific cells. Using nematodes as a new model organism, the lab aims to elucidate the mechanism and to develop new chromosome-editing tools.
*Illustrative imageGenome evolution seen through a sister-species nematode
C. inopinata is a sister species of the model organism C. elegans, yet its body is more than twice as large and its way of life is very different. By comparing the two species, the lab investigates how genomes evolve, focusing in particular on the role of transposons.
*Illustrative imageSparganum proliferum, a mysterious parasite
Sparganum proliferum is a poorly understood parasite related to tapeworms and is the cause of proliferative sparganosis. The lab continues to rear and maintain it, and carries out a variety of experiments and analyses using the worms.
*Illustrative imageMechanisms of parasitism, immunity, and longevity
Nematodes of the genus Strongyloides, which are parasites, have a unique life cycle. The lab aims to elucidate the mechanisms of parasitism, how these worms manipulate the immune system (allergy), and processes such as longevity and chromosome diminution.
MembersFaculty
The members of Kikuchi Lab consist of faculty, project researchers and postdoctoral researchers, academic specialists, secretaries, doctoral and master's students, and research students.As of 2026
- ProfessorTaisei KikuchiPublications ↗
- Assistant Professor佐藤 一輝
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Caenorhabditis elegans under a light microscope 01” Gannu03 / CC BY-SA 4.0 (cropped)
- Mechanisms of chromosome diminution: “Metaphase chromosomes” Simon Caulton / CC BY-SA 3.0 (cropped)
- Genome evolution seen through a sister-species nematode: “Nematode Caenorhabditis Elegans (cropped)” ГП / CC BY-SA 4.0 (cropped)
- Sparganum proliferum, a mysterious parasite: “Taenia crassiceps” Carolina Miranda Brito / CC BY-SA 3.0 (cropped)
- Mechanisms of parasitism, immunity, and longevity: “Strongyloides stercoralis larva” 作者不詳 / Public domain (cropped)
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