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Ishii Lab
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The lab that uncovers how cancer cells interact with the cells around them.
AboutAbout the lab
Understanding cancer together with its surrounding cells
The Ishii Lab studies the environment formed by cancer cells and the non-cancerous cells around them (the tumor microenvironment).
Fibroblasts in particular act as cells that directly influence the properties of cancer cells.
The lab builds models that mimic the tumor microenvironment in culture dishes, and uses them to investigate the mechanisms by which cancer progresses and those that determine how well drugs work.
It is an affiliated laboratory of the Department of Integrated Biosciences, run by a lab at the Exploratory Oncology Research and Clinical Trial Center (EPOC) of the National Cancer Center Japan.
Key terms
- Tumor microenvironment
- The environment surrounding cancer cells, made up of cells such as fibroblasts and immune cells, together with the materials between them
- Fibroblast
- A cell that fills the spaces within tissue and supports the body by producing collagen and other substances
- in vitro
- Experiments carried out in a test tube or culture dish rather than inside a living organism
ResearchResearch themes
The lab aims to understand the heterogeneous, dynamic environment formed by cancer cells and fibroblasts (tumor microenvironment dynamics). It is part of a field that conducts translational research in close integration with the National Cancer Center Hospital East.
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MembersFaculty
- Visiting ProfessorGenichiro Ishii
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Colon adenocarcinoma - biopsy, high mag” CoRus13 / CC BY-SA 4.0 (cropped)
- Uncovering the dynamics of the tumor microenvironment: “Actin filaments of cardiac fibroblasts” Lorenzo2697 / CC BY 4.0 (cropped)
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