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Matsumoto Lab
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The lab investigates how immune cells avoid attacking the body's own tissues.
AboutAbout the lab
How the immune system distinguishes “self”
The Matsumoto Lab studies how innate immune cells distinguish self from non-self, and how this prevents attacks on the body's own tissues.
In innate immunity, inhibitory receptors that recognize self are thought to prevent attacks on the normal body.
The lab aims to identify the self molecules recognized by inhibitory receptors and to control innate immune responses using antibodies against these receptors.
Key terms
- Innate immunity
- The immune response present from birth that reacts immediately to pathogens entering the body
- Inhibitory receptor
- A receptor on the cell surface that puts the brakes on cell activity when it recognizes its target molecule
- Myeloid cells
- Among white blood cells, cells of the lineage that includes macrophages, monocytes, and neutrophils. They are produced in the bone marrow
ResearchResearch themes
The lab aims to identify the self molecules recognized by inhibitory receptors on innate immune cells, and to control innate immune responses using antibodies. It studies receptors on myeloid cells, including members of the DCIR family.
*Illustrative imageFinding cells that express DCIR family receptors
The lab has produced antibodies that distinguish each of the mouse DCIR family receptors, and is working to determine which myeloid cells express which receptors in various organs.
*Illustrative imageInvestigating the function of DCIR2
DCIR2 recognizes glycans with a distinctive structure. Using mice that cannot synthesize those glycans, the lab will clarify the role DCIR2 plays in the body.
*Illustrative imageNew treatments to suppress inflammation
Excessive inflammation worsens autoimmune diseases, COVID-19, and other conditions. The lab aims to develop therapies that control inflammation by targeting inhibitory receptors on myeloid cells, which are central to inflammatory responses.
MembersFaculty
- Associate ProfessorNaoki MatsumotoPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Macrophage ( )” NIAID / CC BY 2.0 (cropped)
- Finding cells that express DCIR family receptors: “Connective Tissue Human Blood Leukocyte Survey ( )” Berkshire Community College Bioscience Image Library / CC0 (cropped)
- Investigating the function of DCIR2: “White lab mice near” Pogrebnoj-Alexandroff / CC BY-SA 3.0 (cropped)
- New treatments to suppress inflammation: “Human neutrophil ingesting MRSA” National Institutes of Health (NIH) / Public domain (cropped)
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