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Ohto Lab
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The lab seeks to understand how biomolecules work by looking at their three-dimensional shapes.
AboutAbout the lab
Visualizing molecules at work.
Ohto Lab studies structural biology, which aims to understand how biomolecules such as proteins work by examining their three-dimensional structures.
In biology, form and function are closely linked, and the shape of a molecule determines how it binds to other molecules.
Using X-ray crystallography and cryo-electron microscopy, the lab investigates molecular shapes, which cannot be seen with the naked eye, at near-atomic resolution.
Key terms
- Structural biology
- The field that seeks to understand how molecules such as proteins and DNA function by determining their three-dimensional structures
- X-ray crystallography
- A method of determining a molecule's structure by crystallizing it, exposing it to X-rays, and analyzing how the X-rays are scattered
- Cryo-electron microscopy
- A method of determining the three-dimensional structure of molecules by rapidly freezing a sample and observing it with an electron microscope
ResearchResearch themes
The lab uses the methods of structural biology to elucidate how molecules involved in biological phenomena important to biology and medicine work. Its motto is "Visualizing molecules at work."
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MembersFaculty
- ProfessorUmeharu OhtoPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images.
- Top image: “CSIRO ScienceImage 300 Protein Crystals for Use in Experiments” Health Sciences and Nutrition, CSIRO / CC BY 3.0 (cropped)
- The structures of molecules involved in immunity and viral infection: “Myoglobin” →AzaToth / Public domain (cropped)
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