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Tsuchihara Lab
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The lab connects clinical information on cancer with large-scale data such as genomes, aiming for new discoveries.
AboutAbout the lab
Connecting clinical information and data to overcome cancer
Tsuchihara Lab studies cancer by combining clinical information gathered at the National Cancer Center with large-scale analytical data.
The lab integrates data such as genomes, transcriptomes, and microbiomes obtained from patient specimens and cell models to draw out new knowledge.
To do so, it uses bioinformatics techniques, including designing data-processing pipelines and building databases.
Key terms
- Transcriptome
- The entire set of RNA transcribed from DNA in a cell. It shows which genes are active.
- Bioinformatics
- A field that uses computers to organize large amounts of biological data and extract information from it.
- Gut microbiota
- The community of many kinds of bacteria living in the intestine.
NewsLab news
View More ↗ResearchResearch themes
Developing cancer therapies requires quality-assured clinical information and data from multi-layered omics analyses of samples such as patient specimens. The lab aims to make the fullest use of such data gathered at the National Cancer Center to make new discoveries toward overcoming cancer.
*Illustrative imageClassification and Origins of Alternative Promoters
The phenomenon in which a single gene is transcribed from multiple start sites is called alternative promoter usage. The lab comprehensively extracts these promoters across the whole genome and combines them with data such as histone modifications, methylation, and drug response to investigate their significance and mechanisms.
*Illustrative imageDetection and Analysis of CHIP in the Japanese Population
Populations of cells carrying genetic mutations commonly seen in blood cancers can also be found in the blood of healthy people. This is called CHIP (clonal hematopoiesis of indeterminate potential). Using a database of Japanese individuals, the lab clarifies its characteristics and explores how to distinguish it from cases that lead to disease.
*Illustrative imagePan-Cancer Analysis of the Gut Microbiota
The lab combines gut microbiota data collected in an industry-academia collaborative pan-cancer research project with clinical information and cancer genome information. It aims to clarify, across many types of cancer, how the gut microbiota relates to disease status and treatment effects.
MembersFaculty
The members of Tsuchihara Lab are the division director, unit director, researchers, physician-scientists, and doctoral and master's students from the cooperative graduate school program.
- Visiting ProfessorKazuya Tsuchihara
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Vlsci pan e small-2” Vlsci / CC BY-SA 3.0 (cropped)
- Classification and Origins of Alternative Promoters: “RNA Polymerase” Maria Voigt and PDB-101 / CC BY 4.0 (cropped)
- Detection and Analysis of CHIP in the Japanese Population: “Peripheral blood smear” Microrao / CC BY-SA 4.0 (cropped)
- Pan-Cancer Analysis of the Gut Microbiota: “BacteroidesFragilis Gram” Content Providers(s): CDC/Dr. V.R. Dowell, Jr. / Public domain (cropped)
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