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Advanced Structural Science Lab
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The lab studies structural biology, using cryo-electron microscopy to reveal the shapes of receptors in the cell membrane.
AboutAbout the lab
Understanding how proteins work from their shapes
The Danev Lab (Advanced Structural Science) uses cryo-electron microscopy to study the relationship between the structure and function of proteins and cellular components.
The lab aims to reveal the structures of important molecules such as cell membrane receptors, and to use them to understand how diseases arise and to develop therapeutic drugs.
The lab also works on improving cryo-electron microscopy itself, including sample preparation, automation, and image contrast.
Key terms
- Cryo-electron microscopy
- A method in which a sample is rapidly frozen and imaged with an electron microscope to determine the three-dimensional structures of proteins and other molecules
- G protein-coupled receptor
- A large group of proteins in the cell membrane that receive signals from outside the cell and pass them into the cell. They are the targets of many drugs
- Single-particle analysis
- A method that collects electron microscope images of many individual molecules and combines them to reconstruct a three-dimensional structure
ResearchResearch themes
The lab aims to clarify the relationship between the structure and function of proteins and cellular components, and to apply it to understanding the mechanisms of chronic diseases and developing effective treatments. It pursues structural studies with cryo-electron microscopy alongside the development of new methods for the technique.
*Illustrative imageThree-dimensional structures of membrane receptors
The lab studies G protein-coupled receptors, which are involved in many diseases and are the largest group of drug targets. Using single-particle analysis with cryo-electron microscopy, it determines the structures of complexes in which these receptors are bound to substances in the body or to synthetic compounds.
*Illustrative imageNew methods in cryo-electron microscopy
Cryo-electron microscopy is developing rapidly, and the lab improves the technique mainly from the experimental side. It plans to extend this work to the development of deep learning and data processing methods in the future.
MembersFaculty
- ProfessorRadostin DanevPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Titan Krios University of Leeds” Hiramano92 / CC BY-SA 4.0 (cropped)
- Three-dimensional structures of membrane receptors: “XBio illustration – G Protein Coupled Receptor (GPCR)” explorebiology / CC BY 4.0 (cropped)
- New methods in cryo-electron microscopy: “Cryo EM Grid (NIH BioArt )” Courtesy of NIAID Alex Stewart / Public domain (cropped)
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