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Vaccine Science Lab
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The lab uncovers how vaccines drive the immune system and develops new vaccines.
AboutAbout the lab
Exploring the science of vaccines
The Vaccine Science Lab studies how vaccines activate the body's immune system.
The lab investigates how the immune system recognizes nucleic acids (DNA and RNA) derived from pathogens and the body's own cells, and what responses they trigger.
Using this knowledge, the lab works on developing nucleic acid-based vaccines, adjuvants, and immunotherapies.
The lab aims to provide an environment where students can learn broadly, from basic immunology research to practical vaccine development.
Key terms
- Adjuvant
- A substance added to a vaccine to strengthen the immune response
- Nucleic acid
- A molecule, such as DNA or RNA, that carries genetic information
- Innate immunity
- An immune mechanism that the body naturally has, which responds immediately to invading pathogens
NewsLab news
An associate professor received the Best Poster Award at JCS2026
A project researcher and a graduate student received the Outstanding Poster Award at the USJCMSP 26th International Conference on Emerging Infectious Diseases
An associate professor won second place at the Research Achievement Presentation Meeting of the Institute of Medical Science, The University of Tokyo
An assistant professor's review article was published in Current Opinion in Virology
A paper by a collaborating researcher was published in npj Vaccines
ResearchResearch themes
The lab studies how nucleic acids regulate immunity, and what that regulation means, in infectious diseases and other immune-related diseases. It develops nucleic acid-based vaccines, adjuvants, and immunotherapies, with the aim of realizing "Bench to Clinic."
*Illustrative imageHow vaccines drive the immune system
Vaccines are one of the most successful medical technologies, yet their molecular mechanisms remain unclear. The lab aims to clarify, at the molecular level, how vaccines and adjuvants transmit signals inside cells and between cells through innate immune receptors.
*Illustrative imageDeveloping next-generation adjuvants
Depending on how they are used, adjuvants can be either poison or medicine. To bring out their benefits while suppressing side effects, the lab develops adjuvants that use nucleic acids such as DNA and RNA, as well as adjuvants that combine these with technologies for delivering them to targeted tissues and cells.
MembersFaculty
The members of the Vaccine Science Lab consist of faculty, project researchers, graduate students, research trainees, collaborating researchers, academic specialist staff, temporary agency staff, secretaries, and operations support staff.As of 2026
- ProfessorKen J IshiiPublications ↗
- Associate ProfessorNegishi HideoPublications ↗
- Project Associate ProfessorMisako NakayamaPublications ↗
- Assistant ProfessorBurcu Temizoz
- Assistant ProfessorTomoya HayashiPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images.
- Top image: “BioFarma vaccine vials Bandung” Ümit Kartoğlu for VOA / Public domain (cropped)
- How vaccines drive the immune system: “Dendritic Cell (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Developing next-generation adjuvants: “Vaccine Vial (NIH BioArt 536)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
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