LAB LOGA page on LabLog, a review site (not the lab's official page)
RNA Regulation Lab
Machine-translated · View original
The lab investigates cellular quality control, the system that detects and removes errors made during protein synthesis.
AboutAbout the lab
Exploring the quality control mechanisms of protein synthesis
The RNA Regulation Lab studies the quality control mechanisms that allow cells to synthesize proteins accurately.
When abnormal proteins accumulate in a cell, many cellular functions are impaired.
The lab investigates, at the molecular level, quality control mechanisms such as ribosome-associated quality control (RQC), which monitors for aberrant translation and degrades partially synthesized proteins.
The lab aims to contribute to the understanding of neurodegenerative diseases such as Alzheimer's and Parkinson's disease and of aging, and to provide a foundation for drug discovery.
Key terms
- Translation
- The cellular process in which the genetic information written in mRNA is read and amino acids are linked together to make a protein
- Ribosome
- The molecular machine in the cell that carries out translation and makes proteins
- Ubiquitination
- Attaching a small protein called ubiquitin as a tag, which determines the protein's fate, such as degradation
- Endoplasmic reticulum
- A membrane structure inside the cell where proteins to be secreted from the cell, among others, are made and folded into shape
NewsLab news
A paper co-first-authored by a doctoral student was published in Molecular Cell
A master's student received a Poster Award at the 25th University of Tokyo Life Science Symposium
A doctoral student received the Graduate School of Frontier Sciences Dean's Award for FY2025
Prof. Inada's review article was published in Nature Structural & Molecular Biology
ResearchResearch themes
The lab analyzes, at the molecular level, the quality control mechanisms that recognize and remove abnormal proteins in cells. It aims to understand diseases caused by the accumulation of abnormal proteins and to clarify the molecular basis for drug discovery.
*Illustrative imageQuality control of aberrant translation
The lab studies ribosome-associated quality control (RQC), which detects ribosomes stalled during translation, dissociates them, and degrades the partially synthesized proteins, as well as no-go decay (NGD), which cleaves stalled mRNAs.
*Illustrative imageQuality control of nonfunctional ribosomes
The lab studies nonfunctional ribosome decay (NRD), the mechanism that detects and degrades abnormal ribosomes that can no longer decode codons correctly. It focuses on the ubiquitin marks attached to specific sites on ribosomal proteins and the enzymes that attach them.
*Illustrative imageRibosome modification in response to stress
Using budding yeast, the lab examines how ribosome ubiquitination regulates translation when stress arises from the accumulation of abnormal proteins in the endoplasmic reticulum.
*Illustrative imageTranslational quality control and disease
When ribosome function declines, defective proteins accumulate and impair a wide range of cellular functions. Building on the mechanisms that detect and remove ribosomal abnormalities, the lab is attempting to develop ways to improve translational fidelity.
MembersFaculty
The members of the RNA Regulation Lab consist of faculty, technical specialists, academic specialists, secretaries, and doctoral and master's students.As of 2026
- ProfessorToshifumi InadaPublications ↗
- LecturerSihan LiPublications ↗
- Assistant ProfessorSuzuki ToruPublications ↗
- Project Assistant ProfessorSatoshi HashimotoPublications ↗
VoicesStudent voices
Ratings and reviews reflect the experiences of individual current or former students, not the lab's official views. Whether a lab has reviews, or how many, says nothing about the lab itself.
Students who take part in an interview may receive a thank-you gift worth ¥1,000, regardless of what they say.
Student ratings (0 students)
--
--
--
--
--
--
Student voices answer questions like these
- What's great about this lab?
- What did you learn after joining?
- What's the vibe, and what is the professor like?
- Who is this lab for?
- Where do graduates go?
Your experience can help younger students choose their lab. Your name won't be shown.
Write a lab reviewAnonymous · Your draft is saved if you stopRelatedLabs similar to RNA Regulation Lab
Molecular Inflammation and Immunology Lab (Toyama-Sorimachi Lab)Faculty of Science, Department of Biophysics and BiochemistryMolecular inflammation and immunology (strategies for contro…
Suga LabFaculty of Science, Department of ChemistryArtificial ribozymes, genetic code reprogramming, translatio…
Shibuya LabFaculty of Science, Department of Information ScienceInformatics analysis of big data in genomic medicine
Tsunoda LabFaculty of Science, Department of Bioinformatics and Systems BiologyElucidation of relationships between disease and biological …The information on this page is compiled by the LabLog team from the lab's public information and interviews. For corrections or removal requests, please contact LabLog, not the lab.
Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Ribosome mRNA translation en” LadyofHats / Public domain (cropped)
- Quality control of aberrant translation: “Ubiquitin cartoon” en:User:Rogerdodd / Public domain (cropped)
- Quality control of nonfunctional ribosomes: “Diubiquitin-lysine-48” Rogerdodd / CC BY-SA 3.0 (cropped)
- Ribosome modification in response to stress: “S cerevisiae under DIC microscopy” Masur / Public domain (cropped)
- Translational quality control and disease: “Culture of rat brain cells stained with antibody to MAP2 (green), Neurofilament (red) and DNA (blue)” GerryShaw / CC BY-SA 3.0 (cropped)
- Related lab (Molecular Inflammation and Immunology Lab (Toyama-Sorimachi Lab)): “Macrophage ( )” NIAID / CC BY 2.0 (cropped)
- Related lab (Suga Lab): “TRNA-Phe yeast 1ehz” Yikrazuul / CC BY-SA 3.0 (cropped)
- Related lab (Shibuya Lab): “Pleiades supercomputer racks 2” Oleg Alexandrov / CC BY-SA 4.0 (cropped)
- Related lab (Tsunoda Lab): “IBM Quantum System One” OJB Quantum / CC BY 4.0 (cropped)
About LabLog
LabLog is a lab review app for students only. Student members at each university interview students in labs and publish what they say. Student voices can only be read by students who sign up with a university email address. Operated by bestiee Inc.
Learn more about LabLog ↗Search engines and AI may reference the basic lab info and rating summaries on this page and the description of LabLog. Student voices are for student members only. Automated collection by programs (scraping, or input to or training of AI) is prohibited under Article 8 of the Terms of Service. If you need data for research or analysis, please contact us.