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Genome Medical Science Lab
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The lab studies the complete genomes of diseases such as cancer, aiming to develop new treatments and prevention.
AboutAbout the lab
Understanding disease through the genome
The lab studies a wide range of diseases, including cancer and lifestyle-related diseases, from the perspective of the genome.
Using state-of-the-art genome analysis and bioinformatics technologies, the lab reveals new genes involved in disease and the full landscape of genomic alterations.
The lab aims to find therapeutic targets and biomarkers, and to achieve breakthroughs that lead to treatment, diagnosis, and prevention.
Key terms
- Genome
- The complete set of genetic information (DNA) of an organism
- Biomarker
- A substance or genetic change in the body that provides clues about the presence or progression of a disease, or the effectiveness of treatment
- Colibactin
- A toxin produced by some strains of E. coli. It damages the DNA of cells and causes mutations
NewsLab news
View More ↗ResearchResearch themes
The lab comprehensively investigates cancer and other diseases that are currently difficult to cure, based on molecular genomics. It aims to discover new genes and pathways that can serve as targets for treatment and prevention, as well as biomarkers.
*Illustrative imageRegional and Age Differences in Colorectal Cancer Mutations
In an international collaborative study, the lab examined the genomes of colorectal cancers from 11 countries. It showed that mutations caused by colibactin, a mutagen produced by bacteria, are more common in countries with high incidence rates and in colorectal cancers that developed before age 40.
*Illustrative imageCancer Development in Hereditary Gastric Polyposis
In GAPPS, a hereditary disease in which many polyps form in the stomach, the lab read DNA and RNA from normal mucosa, polyps, and cancer. It showed that KRAS mutations, in addition to APC mutations, are involved in the development of cancer.
*Illustrative imageCutaneous Lupus Erythematosus and Senescent Cells
In cutaneous lupus erythematosus, the lab clarified the mechanism by which senescent basal cells of the epidermis trigger an immune attack on surrounding normal cells. It also showed that a drug that removes senescent cells alleviates skin symptoms in mice.
MembersFaculty
- ProfessorTatsuhiro ShibataPublications ↗
- LecturerAtsushi NiidaPublications ↗
- Assistant ProfessorKazuki TakahashiPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Adenocarcinoma of the colon-histology” Netha Hussain / CC BY-SA 3.0 (cropped)
- Regional and Age Differences in Colorectal Cancer Mutations: “Escherichia coli (SEM)” CDC/Evangeline Sowers, Janice Carr / Public domain (cropped)
- Cancer Development in Hereditary Gastric Polyposis: “Fundic gland polyp, low mag” CoRus13 / CC BY-SA 4.0 (cropped)
- Cutaneous Lupus Erythematosus and Senescent Cells: “502 Layers of epidermis (no labels)” OpenStax College Anatomy & Physiology, Connexions Web site. http://cnx.org/content/col11496/1.6/ / CC BY 3.0 (cropped)
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