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Matsuda-Tanikawa Lab
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The lab uses genome analysis to uncover the causes of diseases such as cancer.
AboutAbout the lab
Uncovering the causes of disease from the genome
The Matsuda-Tanikawa Lab uses genome analysis to study the mechanisms by which diseases, particularly cancer, arise.
Cancer is a disease caused by abnormalities in genes (DNA), and the lab investigates how changes in DNA lead to disease.
One of the main research themes is analyzing the function of p53, a tumor suppressor gene.
The lab aims to enable disease prevention, early detection, and medicine tailored to each individual's constitution (personalized medicine).
Key terms
- Tumor suppressor gene
- A gene that prevents cells from becoming cancerous. When it is damaged, cancer becomes more likely to develop.
- Single nucleotide polymorphism (SNP)
- A position in a DNA sequence where a single letter differs from person to person. Often abbreviated as SNP.
- Next-generation sequencer
- A device that can read large amounts of DNA sequence quickly and at low cost.
ResearchResearch themes
Through genome analysis, the lab clarifies the causes of diseases, with the aim of realizing a society of healthy longevity. It works on elucidating the mechanisms of disease onset using biobank samples, as well as on research into the tumor suppressor gene p53.
*Illustrative imageElucidating the mechanisms of disease onset
The lab is involved in the management and operation of BioBank Japan, and investigates genetic predisposition to disease susceptibility by examining differences in DNA sequences between people with a disease and healthy people (single nucleotide polymorphisms: SNPs). Using original serum-based analyses and genome editing, it works to uncover how diseases develop.
*Illustrative imageSuppression of tumorigenesis by p53
p53 is a tumor suppressor gene that is abnormal in about half of all cancers. Using comprehensive analyses, including next-generation sequencing, the lab is working to elucidate how p53 suppresses tumorigenesis and to explore new therapeutic strategies.
MembersFaculty
The members of the Matsuda-Tanikawa Lab consist of faculty, project researchers, doctoral and master's students, research students and special research students, and staff.As of 2026
- ProfessorMatsuda KouichiPublications ↗
- Associate ProfessorChizu Tanikawa
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “DNA Helix CPK” Ude / Public domain (cropped)
- Elucidating the mechanisms of disease onset: “Hinge top vials on a vial rack” Greg Emmerich / CC BY-SA 2.0 (cropped)
- Suppression of tumorigenesis by p53: “Fluorescence microscopy of the DNA of the oral cancer cells” Korinna / CC BY 4.0 (cropped)
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