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Cell Regulation Lab
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The lab studies how hematopoietic stem cells, which produce blood, work, with the aim of applying its findings to regenerative medicine and gene therapy.
AboutAbout the lab
From basic research to application
The Cell Regulation Lab focuses on adult stem cells and studies how the state of cells is regulated.
The main subject of its research is hematopoietic stem cells, which keep producing blood cells throughout life.
The lab aims to understand these regulatory mechanisms and, by manipulating them, to explore the possibility of new therapies.
Key terms
- Hematopoietic stem cell
- A cell found in the bone marrow that gives rise to all types of blood cells, including red and white blood cells
- Self-renewal
- The ability of a stem cell, when it divides, to produce a stem cell with the same properties as itself
- Bone marrow microenvironment
- The environment within the bone marrow, formed by blood vessels, mesenchymal stromal cells, and other components, that protects and nurtures blood cells
NewsLab news
Paper by a researcher published in Exp Hematol
Paper by a doctoral student published in Molecular Therapy Oncology
A member received the Academic Encouragement Award from the Japan Society for Cytometry
Assistant Professor Yogo received the IMSUT Outstanding Young Investigator Award
A researcher received the CKD Frontier Award at the 15th CKD Frontier Meeting
ResearchResearch themes
Using hematopoietic stem cells as a model, the lab studies how stem cells produce different types of blood cells while self-renewing. It aims to apply these findings to the development of safe and effective regenerative medicine and gene therapy.
*Illustrative imageSelf-Renewal and Differentiation of Hematopoietic Stem Cells
The lab is uncovering how hematopoietic stem cells continue to self-renew and differentiate into multiple lineages, using methods that examine individual stem cells both in vitro and in vivo.
*Illustrative imageGene Therapy Using Human Hematopoietic Stem Cells
Toward gene therapy for blood diseases, the lab conducts the basic research needed to establish methods for isolating, expanding, and preserving hematopoietic stem cells, as well as methods for verifying their quality and safety, and explores treatments suited to each disease.
*Illustrative imageBone Marrow Microenvironment
Focusing on the mesenchymal stromal cells (MSCs) that form the bone marrow environment, the lab investigates their role in supporting hematopoiesis and their relationship to age-related changes in the bone marrow and to genetic damage in hematopoietic cells.
MembersFaculty
The members of the Cell Regulation Lab consist of faculty, researchers, collaborating researchers, technical staff, administrative staff, doctoral and master's students, and research students.As of 2026
- ProfessorSatoshi YamazakiPublications ↗
- Associate ProfessorYosuke TanakaPublications ↗
- Assistant ProfessorTakao YogoPublications ↗
- Project Assistant ProfessorJeon HyojungPublications ↗
- Project Assistant ProfessorYuko KawanoPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images.
- Top image: “Bone Marrow (NIH BioArt 56)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Self-Renewal and Differentiation of Hematopoietic Stem Cells: “Hematopoietic Stem Cell (NIH BioArt 200)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Gene Therapy Using Human Hematopoietic Stem Cells: “Gene therapy” 作者不詳 / Public domain (cropped)
- Bone Marrow Microenvironment: “Section of bone marrow tissue (Prussian blue stain)” Dr. Gordon D. McLaren / Public domain (cropped)
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