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Hematopoietic Pathophysiology and Regulation Lab
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The lab unravels blood diseases from both genomic and clinical perspectives.
AboutAbout the lab
From questions born in clinical care to new treatments
The lab studies hematologic malignancies such as leukemia, as well as a wide range of other blood diseases.
Starting from the challenges faced by patients in daily clinical care, the lab aims for a "Bench to Bedside" cycle in which research findings are returned to patients as new diagnostics and treatments.
Using both computational and experimental approaches, the lab works on everything from genomic research and bioinformatics with next-generation sequencers to cell experiments and validation in mouse models.
Working as one with the Department of Hematology and Oncology at the affiliated hospital, the lab carries out clinical care, research, and education for blood diseases.
Key terms
- Allogeneic hematopoietic cell transplantation
- A treatment in which blood-forming stem cells are received from a donor and transplanted into the patient
- Clinical sequencing
- A test that examines a patient's gene sequences and uses the results to guide diagnosis and treatment selection
- Graft-versus-host disease
- A complication in which the transplanted donor's immune cells regard the patient's body as foreign and attack it
ResearchResearch themes
Centering on hematologic malignancies and hematopoietic stem cell transplantation, the lab places importance on turning questions that arise in the clinic into research. Starting from challenges in daily clinical care, it aims to develop better treatment strategies through both basic and clinical research.
*Illustrative imageExploring Disease Mechanisms with Genomics and Omics
By combining whole-genome sequencing, RNA-seq, single-cell analysis, and other methods, the lab identifies the genomic abnormalities involved in blood diseases and clarifies what those abnormalities mean within the disease.
*Illustrative imageBringing Whole-Genome Analysis into Clinical Care
For blood diseases that are difficult to diagnose, the lab performs clinical sequencing using whole-exome and whole-genome analysis. It aims to use the results for diagnosis, treatment selection, and prognosis prediction, and to make the analysis practical as a clinical laboratory test.
*Illustrative imageHematopoietic Cell Transplantation and Post-Transplant Immunity
While building clinical evidence centered on allogeneic hematopoietic cell transplantation, the lab uses patient samples to study immune reconstitution after transplantation, graft-versus-host disease, and other post-transplant complications.
*Illustrative imageHTLV-1 and Adult T-cell Leukemia-Lymphoma
Based on clinical information from HTLV-1 carriers and patients with adult T-cell leukemia-lymphoma (ATL), the lab studies the risk of developing ATL, prediction of prognosis, and ways to overcome treatment-resistant disease.
MembersFaculty
The lab's members consist of faculty, postdocs, PhD students, clinical fellows, research assistants, and secretaries.As of 2026
- ProfessorNanya YasuhitoPublications ↗
- Associate ProfessorTakaaki KonumaPublications ↗
- Associate ProfessorKazuaki Yokoyama
- Assistant ProfessorSeiko Kato
- Assistant ProfessorAki Sato
- Assistant ProfessorKoji JimboPublications ↗
- Assistant ProfessorShohei Ando
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Peripheral blood smear of acute promyelocytic leukemia, hypogranular variant, source image (3)” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D.Consent note: Consent from the patient or patient's relatives is regarded as redundant, because of absence of identifiable features (List of HIPAA identifiers) in the media and case information (See also HIPAA case reports guidance). / CC0 (cropped)
- Exploring Disease Mechanisms with Genomics and Omics: “Single Cell RNA Seq (NIH BioArt 767)” NIAID (Ryan Kissinger) / Public domain (cropped)
- Bringing Whole-Genome Analysis into Clinical Care: “Illumina Hiseq 2000 sequencers, BGI Hong Kong sequencing room” Scotted400 / CC BY 3.0 (cropped)
- Hematopoietic Cell Transplantation and Post-Transplant Immunity: “Bone Marrow Transplant” Mugwump12 / CC BY-SA 3.0 (cropped)
- HTLV-1 and Adult T-cell Leukemia-Lymphoma: “HTLV-1 and HIV-1 EM 8241 lores” Content Providers: CDC / Public domain (cropped)
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