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Clinical Genome Oncology Lab
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The lab studies the genomes of gastrointestinal cancers to create new diagnostics and treatments.
AboutAbout the lab
From cancer genome analysis to medical development
The Clinical Genome Oncology Lab conducts a wide range of research, from basic to developmental research, in order to bring new medicine to people suffering from cancer.
By examining cancer genomes, gene expression, and protein-protein binding, the lab has identified molecules involved in the onset and progression of gastrointestinal cancers such as colorectal cancer, bile duct cancer, and pancreatic cancer.
The lab clarifies how these molecules function and are regulated, and examines whether therapies targeting them are feasible.
In addition to creating animal models of cancer and searching for drug candidates, the lab has begun research on precision medicine using artificial intelligence (AI), making use of the affiliated hospital.
Key terms
- Wnt signaling
- One of the ways cells transmit signals that regulate cell proliferation and differentiation. Abnormalities are linked to colorectal cancer and liver cancer.
- Next-generation sequencer
- A device that reads large amounts of DNA sequence at once and at high speed.
- Organoid
- A small tissue resembling an organ or tumor, made in a test tube by growing cells in three dimensions.
NewsLab news
Collaborative paper with Iwate Medical University published in Twin Res Hum Genet
Paper identifying the cell of origin of pseudomyxoma peritonei accepted by Pathology - Research and Practice
Associate Professor's review article accepted by Cancer Science
Doctoral student's paper accepted by Communications Biology
ResearchResearch themes
The lab aims to elucidate the mechanisms of carcinogenesis and to develop methods for diagnosing, treating, and preventing cancer. It works on gene analysis of gastrointestinal cancers, new mouse models of carcinogenesis, cancer genome analysis, and the search for therapeutic drugs.
*Illustrative imageHow gastrointestinal cancers arise and progress
The lab examines gene expression in colorectal cancer, liver cancer, and intrahepatic cholangiocarcinoma, and also performs whole-genome analysis in collaboration with the Human Genome Center. Focusing in particular on abnormalities in Wnt signaling, it searches for genes that act downstream and investigates their functions.
*Illustrative imageNew mouse models of carcinogenesis
The lab reproduces in mice the gene mutations seen in human cancers to create new carcinogenesis models. It found that mice carrying a combination of a Kras mutation and Pten deletion in the liver develop tumors resembling human intrahepatic cholangiocarcinoma, and it studies the mechanisms of carcinogenesis using cell lines and organoids.
*Illustrative imageCancer genome analysis and AI
Together with the Human Genome Center and others, the lab uses next-generation sequencers to find mutations that cause hereditary diseases as well as mutations that have arisen in tumors. Aiming at personalized medicine, it is also building analysis systems that use artificial intelligence.
*Illustrative imageSearching for molecular targeted cancer drugs
To find drugs that suppress Wnt/β-catenin signaling for cancer treatment, the lab developed an assay with high sensitivity and specificity. It searches for candidates in large libraries of small molecules and natural products.
MembersFaculty
The members of the Clinical Genome Oncology Lab consist of faculty, academic specialist staff, and doctoral and master's students.As of 2026
- ProfessorYoichi FurukawaPublications ↗
- Associate ProfessorKiyoshi YamaguchiPublications ↗
- Assistant ProfessorSaya NakagawaPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Colon Adenocarcinoma, Whole-Mount Scan ( )” Ed Uthman from Houston, TX, USA / CC BY 2.0 (cropped)
- How gastrointestinal cancers arise and progress: “Adenocarcinoma of the colon-histology” Netha Hussain / CC BY-SA 3.0 (cropped)
- New mouse models of carcinogenesis: “Lab mice 436262” Understanding Animal Research / CC BY 2.0 (cropped)
- Cancer genome analysis and AI: “Illumina MiSeq sequencer” Konrad Förstner / CC0 (cropped)
- Searching for molecular targeted cancer drugs: “Assay plate carousel” National Institute of Allergy and Infectious Diseases / Public domain (cropped)
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