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Hematology and Tumor Biology Lab
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The lab uncovers how blood cancers arise from genetic abnormalities.
AboutAbout the lab
Understanding how blood cancers develop, starting from genes.
The Hematology and Tumor Biology Lab studies how blood cancers (hematologic malignancies) arise from genetic abnormalities.
The lab was launched in May 2024.
Using patient samples and mouse models that recapitulate the disease, the lab combines omics and single-cell analyses to examine abnormalities in cancer cells in detail.
The lab aims to connect these findings to translational research that benefits clinical practice.
Key terms
- Hematologic malignancy
- A collective term for cancers arising from blood-forming cells, such as leukemia and myelodysplastic syndromes
- Omics analysis
- Analysis that comprehensively measures the molecules inside cells, such as gene sequences and how genes function
- Clonal evolution
- The process by which a population of cells carrying gene mutations expands by acquiring further mutations and changes its characteristics
NewsLab news
Review article co-first-authored by a graduate student and a research student published
Research trainee selected for the American Society of Hematology (ASH) Abstract Achievement Award
Associate Professor Kon appointed as an affiliated faculty member of the Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences
Associate Professor Kon appointed as an affiliated faculty member of the Department of Internal Medicine, Graduate School of Medicine
Hematology and Tumor Biology Lab launched
ResearchResearch themes
Focusing on blood cancers, the lab studies the molecular mechanisms by which newly discovered genetic abnormalities cause cancer. It uses patient samples and mouse models, combining data science through omics analysis with methods such as gene editing.
*Illustrative imageGenomic Analysis of Blood Cancers
Targeting myeloid hematologic malignancies such as myelodysplastic syndromes (MDS), the lab uses next-generation sequencing to comprehensively search for gene mutations and investigates the genetic abnormalities involved in disease onset.
*Illustrative imageExploring the Pathology of Genetic Abnormalities in Mice
The lab creates mouse models of newly discovered gene mutations and studies how clones of hematopoietic stem cells progress to cancer. It also uses omics analyses such as RNA-seq, ATAC-seq, and Hi-C.
*Illustrative imageInherited Genetic Abnormalities and Blood Cancers
Focusing on germline mutations in DDX41 found in familial myeloid neoplasms that develop in older age, the lab investigates how cells carrying the mutation come to be selected for and expand later in life.
*Illustrative imageMechanisms of Clonal Evolution in Cancer
Using single-cell analysis of mouse models and patient samples, the lab examines how the order in which gene mutations are acquired, interactions with surrounding cells (the niche), and chronic inflammation affect changes in cancer cell populations.
MembersFaculty
The members of the Hematology and Tumor Biology Lab consist of faculty, academic specialist staff, doctoral and master's students, research students, and research trainees.As of 2026
- Associate ProfessorAyana KonPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images.
- Top image: “Acute Promyelocytic Leukemia, Marrow Aspirate ( )” Ed Uthman from Houston, TX, USA / CC BY 2.0 (cropped)
- Genomic Analysis of Blood Cancers: “DNA-Sequencers from Flickr 57080968” Flickr user jurvetson / CC BY 2.0 (cropped)
- Exploring the Pathology of Genetic Abnormalities in Mice: “Lab mice 436262” Understanding Animal Research / CC BY 2.0 (cropped)
- Inherited Genetic Abnormalities and Blood Cancers: “Megakaryocytes in MDS (RAEB and 5q-chromosome abnormality)” The Armed Forces Institute of Pathology (AFIP) / Public domain (cropped)
- Mechanisms of Clonal Evolution in Cancer: “Fluidigm C1 Single-Cell Auto Prep system” Konrad Förstner / CC BY 2.0 (cropped)
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