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Regenerative Medicine Lab
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The lab creates "organs" such as mini-livers from human iPS cells.
AboutAbout the lab
Creating organs from iPS cells
The lab uses human iPS cells to create, by artificial means, three-dimensional "organs" composed of many different types of cells.
Organ transplantation faces a shortage of donor organs, and the lab aims to develop a new form of transplantation medicine that can replace it.
Centered on liver organoids (mini-livers), the lab is also working on preparations for clinical trials, experiments in space, and cancer research.
Key terms
- iPS cells
- Artificially created stem cells that can both self-renew and differentiate into many types of cells
- Organoid
- A small piece of tissue, grown in culture from stem cells or similar cells, that has an organ-like structure and function
- Tumor microenvironment
- The environment around cancer cells formed by immune cells, blood vessels, fibroblasts, and other components, which influences the properties of the cancer
NewsLab news
A doctoral student published a paper on liver tissue derived from iPS cells
A doctoral student received the ERA Award from the Department of Computational Biology and Medical Sciences
A doctoral student's research was selected as an Outstanding Doctoral Thesis by the Department of Computational Biology and Medical Sciences
A graduate published a paper on a method for producing liver organoids containing Kupffer cells
A doctoral student published a paper on the maturation of liver organoids
ResearchResearch themes
The lab is developing its own organoid culture technology that reconstitutes human organs made of multiple cell types from human iPS cells. It applies this technology to transplantation medicine as an alternative to organ transplantation, and to cancer research.
*Illustrative imageToward clinical trials with liver organoids
Using human liver organoids made from human iPS cells, the lab is preparing for clinical trials targeting conditions such as urea cycle disorders.
*Illustrative imageBuilding liver tissue outside the body
Drawing on knowledge of how the liver forms its three-dimensional structure during development, the lab aims to reproduce tube structures such as bile ducts and blood vessels, together with the arrangement of hepatocytes, to create mini-livers closer to those in the body.
*Illustrative imageMaking human organs in space experiments
The lab developed a culture technique that gathers liver buds (the primordia of the liver) made from iPS cells onto a large-vessel structure, and carried out a verification experiment on the International Space Station. It also plans to investigate how gravity affects the growth and function of the liver.
*Illustrative imageRecreating the microenvironment of pancreatic cancer
Using cancer cells obtained from surgical specimens of pancreatic cancer, together with mesenchymal cells and vascular endothelial cells made from iPS cells, the lab created organoids that reproduce the microenvironment characteristic of pancreatic cancer. These organoids are used to elucidate the mechanisms of immune suppression and to search for therapeutic drugs.
MembersFaculty
The members of the Regenerative Medicine Lab consist of faculty, project researchers, academic specialist staff, visiting researchers, doctoral and master's students, special research students, and secretaries.As of 2026
- ProfessorHideki TaniguchiPublications ↗
- Associate ProfessorNaoki TanimizuPublications ↗
- Assistant ProfessorTakayoshi ObaPublications ↗
- Project Assistant ProfessorYasuharu Ueno
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Human induced pluripotent stem cell colony ( )” NIH Image Gallery from Bethesda, Maryland, USA / Public domain (cropped)
- Toward clinical trials with liver organoids: “Liver Lobule (NIH BioArt 565)” NIH NIAID / CC BY 4.0 (cropped)
- Building liver tissue outside the body: “Liver reticulin” Nephron / CC BY-SA 3.0 (cropped)
- Making human organs in space experiments: “Iss072e277661 (Nov 23, 2024) --- NASA astronaut and Expedition 72 Flight Engineer Nick Hague services research hardware for the Rhodium Biomanufacturing-03 experiment inside the International Space Station's Kibo labo” NASA Johnson Space Center / Public domain (cropped)
- Recreating the microenvironment of pancreatic cancer: “Adenocarcinoma of Pancreas, FNA ( )” Ed Uthman from Houston, TX, USA / CC BY 2.0 (cropped)
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