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Somatic Stem Cell Lab
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A lab that applies cells from the umbilical cord and cord blood to immune cell therapy and regenerative medicine.
AboutAbout the lab
Putting the power of somatic stem cells to work in treatment
The lab studies the properties of somatic stem cells obtained from the umbilical cord and cord blood, and applies them to immune cell therapy and regenerative medicine.
Mesenchymal cells gather at sites of inflammation and damaged tissue, where they suppress inflammation and repair tissue; the lab focuses in particular on those derived from the umbilical cord.
In collaboration with the Cord Blood and Umbilical Cord Bank at the Institute of Medical Science Hospital, the lab aims to apply these cells to new treatments.
To deliver high-quality cells, the lab also aims to use a cell processing facility to manufacture regenerative medical products and their raw materials.
Key terms
- Mesenchymal cells
- Cells found in the stroma of organs throughout the body. They multiply themselves, suppress inflammation, and repair tissue.
- Cord blood
- Blood contained in the umbilical cord and placenta. It contains the stem cells that give rise to blood cells.
- Immune cell therapy
- A treatment method in which cells with immune function are prepared outside the body and given to patients to treat disease.
ResearchResearch themes
Using cord blood and umbilical cord-derived mesenchymal cells, the lab explores new immune and regenerative gene and cell therapies with high quality and safety. It is also responsible for operating the Institute of Medical Science's cell processing facility for translational research.
*Illustrative imagePutting umbilical cord-derived cells to work in treatment
The lab explores new cell therapies using cord blood and umbilical cord-derived mesenchymal cells. In joint work with companies, it uses mice to investigate applications to acute radiation injury, cleft palate, and hemorrhagic arthropathy, as well as the effect of speeding up the engraftment of hematopoietic stem cells.
*Illustrative imageOperating the cell processing facility
To enable high-quality manufacturing for translational research in gene and cell therapy, the lab keeps the Institute of Medical Science's cell processing facility (IMSUT-HLC-CPF) clean and operates it. In 2023, this facility became the first at a national university to obtain a permit to manufacture for treatments using umbilical cord-derived mesenchymal cells.
MembersFaculty
- Associate ProfessorTokiko Nagamura-InouePublications ↗
- Associate ProfessorHidekazu Nishikii
- Project Assistant ProfessorKazuhiro Sudo
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Cross section of human umbilical cord immediately after cutting” Grendelkhan / CC BY-SA 4.0 (cropped)
- Putting umbilical cord-derived cells to work in treatment: “Dental pulp stem cells. SEM-BSE” Ivan A. Novikov / CC BY-SA 4.0 (cropped)
- Operating the cell processing facility: “StorageLN” Прокопюк Владимир Юрьевич / CC BY-SA 4.0 (cropped)
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