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Infection Control (Virology) Lab
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A lab that studies the immune response to viral infection, with the aim of developing vaccines.
AboutAbout the lab
How does the body detect and fight viruses?
The Ichinohe Lab studies the immune responses that occur in the body when it is infected with a virus.
To help develop more effective vaccines, the lab investigates how the body recognizes viruses.
Using an influenza virus infection model, the lab also studies the regulation of mucosal immunity and how the gut microbiota regulates virus-specific immune responses.
The lab also works on the mechanisms behind severe COVID-19 and on the development of nasal spray vaccines.
Key terms
- Innate immunity
- The defense mechanisms an organism is born with. They quickly detect foreign substances and respond to them.
- Gut microbiota
- The community of bacteria living in the intestine. It affects immune function not only in the gut but throughout the body.
- Host
- The organism that a virus enters and multiplies in. Here, this means humans, mice, and other animals.
NewsLab news
Study clarifies how SARS-CoV-2 multiplies efficiently at 37°C
IgA antibodies in the airway mucosa found to be important for defense against SARS-CoV-2 variants
Study clarifies how inflammatory cytokines promote severe COVID-19
ResearchResearch themes
The lab investigates how the body recognizes viruses, and how gut bacteria and body temperature affect the severity of disease after infection. It applies these findings to developing vaccines that prevent infection itself.
*Illustrative imageRecognition of Viruses by Innate Immunity
The lab investigates how the body recognizes invisible viruses as foreign. It focuses on the mechanisms that trigger the activation of innate immunity.
*Illustrative imageGut Microbiota and Viral Pneumonia
The lab investigates how the gut microbiota helps to prevent viral pneumonia from becoming severe. It analyzes the link between bacteria in the gut and virus-specific immune responses.
*Illustrative imageImmune Evasion by Viruses
The lab investigates the mechanisms by which viruses escape the host's immune system. It conducts its analyses using an influenza virus infection model.
*Illustrative imagePathogenic Mechanisms That Determine Disease Severity
The lab investigates the mechanisms by which influenza virus and SARS-CoV-2 cause severe disease in humans and animals. It is also working to explain why the Wuhan, Delta, and Omicron strains of SARS-CoV-2 differ in severity.
MembersFaculty
The members of the Ichinohe Lab are faculty and technical assistants.As of 2026
- Associate ProfessorIchinohe TakeshiPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Macrophage ( )” NIAID / CC BY 2.0 (cropped)
- Recognition of Viruses by Innate Immunity: “Macrophage Infected with Francisella tularensis Bacteria ( )” NIAID / CC BY 2.0 (cropped)
- Gut Microbiota and Viral Pneumonia: “Lactobacillus acidophilus SEM” Mogana Das Murtey and Patchamuthu Ramasamy / CC BY-SA 3.0 (cropped)
- Immune Evasion by Viruses: “Novel Coronavirus SARS-CoV-2” NIAID-RML (https://www.niaid.nih.gov/ & https://www.niaid.nih.gov/about/rocky-mountain-laboratories) / CC BY 2.0 (cropped)
- Pathogenic Mechanisms That Determine Disease Severity: “Coronavirus. SARS-CoV-2” Alexey Solodovnikov (Idea, Producer, CG, Editor), Valeria Arkhipova (Scientific Сonsultant) / CC BY-SA 4.0 (cropped)
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