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Hisatsune Lab
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The lab studies the mechanisms of brain aging, with the aim of supporting healthy longevity.
AboutAbout the lab
Contributing to healthy longevity through brain research
The Hisatsune Lab studies how the brain works, with the aim of preventing brain aging and dementia.
The brain was long thought to only decline once we reach adulthood, but the lab's research has shown that the adult brain retains the ability to grow and repair itself.
The lab conducts research on learning and memory using mouse models of Alzheimer's disease, as well as research on preventing brain aging with the cooperation of elderly volunteers.
It has become clear that brain aging can be slowed to some extent by improving lifestyle habits, and the lab hopes to improve brain health and thereby support healthy longevity.
Key terms
- Hippocampus
- A region deep in the brain that is closely involved in learning and memory
- Model mouse
- A mouse engineered to carry genes related to a human disease, created to study how the disease works
- Alzheimer's disease
- The most common form of dementia. It is thought that clumps of protein that build up in the brain trigger the decline of cognitive functions such as memory
NewsLab news
A student received the FY2024 Special Encouragement Award for Doctoral Dissertations
A student received the FY2024 Dean's Award of the Graduate School of Frontier Sciences
A collaborative study found that newly born neurons in the hippocampus are involved in executive function
ResearchResearch themes
Drawing on the ability of the adult brain to grow and repair itself, the lab aims to prevent declines in memory and cognitive function, as well as dementia. It approaches the mechanisms of brain aging from two directions: brain research using model mice, and research conducted with the cooperation of elderly people.
*Illustrative imageNew neurons born in the adult brain
In the hippocampus, which is involved in memory, neurons continue to be replaced even in adulthood. The lab has created mice in which the activity of newly born neurons can be freely switched off, and uses them to investigate the role of these neurons in learning and cognitive function.
*Illustrative imageInvestigating the causes of Alzheimer's disease
Using model mice carrying genes related to the disease, the lab examines the relationships among genetic changes, inflammation in the brain, and declining cognitive function. In addition to behavioral analysis, it also conducts experiments that measure brain activity during learning using MRI.
*Illustrative imageResearch on the brain and diet in older adults
With the cooperation of older residents of Kashiwa City, the lab investigates the relationship between brain function and diet. By analyzing data from older adults, it explores the mechanisms of brain aging, with the aim of controlling aging through diet.
*Illustrative imageSupporting health with digital technology
Looking ahead to the age of 100-year lives, the lab is working to develop healthcare services that use digital technology, building on what has been learned about brain aging.
MembersFaculty
The members of the Hisatsune Lab consist of faculty, academic specialists, and doctoral and master's students.As of 2026
- Associate ProfessorTatsuhiro HisatsunePublications ↗
- Project Assistant ProfessorKeisuke SakuraiPublications ↗
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Ιππόκαμπος ποντικού” Archontia Kaminari / CC BY-SA 4.0 (cropped)
- New neurons born in the adult brain: “Neuronal explosion” AlmudenaFM / CC BY-SA 4.0 (cropped)
- Investigating the causes of Alzheimer's disease: “Alzheimers disease-Beta-amyloid plaque formation” National Institute on Aging / Public domain (cropped)
- Research on the brain and diet in older adults: “DIETA MEDITERRANEA ITALIA” G.steph.rocket / CC BY-SA 4.0 (cropped)
- Supporting health with digital technology: “Architecture-of-the-IoT-for-home-care-systems” Biljana Risteska Stojkoska, Kire Trivodaliev, Danco Davcev / CC BY 4.0 (cropped)
- Related lab (Nutritional Chemistry Lab): “Cultured Rat Hippocampal Neuron ( )” ZEISS Microscopy from Germany / CC BY 2.0 (cropped)
- Related lab (Radiation Plant Physiology Lab): “Soybean Plants in the Field ( )” United Soybean Board / CC BY 2.0 (cropped)
- Related lab (Food Chemistry Lab (Arai Lab)): “Macrophage ( )” NIAID / CC BY 2.0 (cropped)
- Related lab (Nutrition and Life Sciences Lab): “Human iPS cells colonies” Christine Hale, Amy Yeung, David Goulding, Derek Pickard, Kaur Alasoo, Fiona Powrie, Gordon Dougan ほか
（PLOS ONE） / CC BY 4.0 (cropped)
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