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Organic Synthetic Chemistry Lab (Kobayashi Lab)
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A lab that uses water and hydrogen to explore environmentally friendly ways of making materials.

AboutAbout the lab
Environmentally friendly new ways to make materials
The Kobayashi Lab studies chemical transformation and material transformation methods that place a small burden on the environment.
The lab has worked on reactions that use water as the solvent and on immobilized catalysts that can be recovered and reused repeatedly.
It is also advancing the precise synthesis of pharmaceuticals and other compounds through flow synthesis, in which solutions are passed continuously through the reaction setup.
Building on organic synthetic chemistry, the lab conducts education and research across the fields of science, engineering, pharmaceutical sciences, and agriculture.
Key terms
- Catalyst
- A substance that helps a reaction proceed while remaining unchanged itself
- Immobilized catalyst
- A metal catalyst incorporated into a polymer or similar support so that it can be recovered after use and used again
- Flow synthesis
- A method in which, instead of carrying out reactions flask by flask, a solution is passed continuously through a column so that the reaction proceeds without interruption
NewsLab news
Paper published on the flow synthesis of evocalcet
Paper published on the continuous-flow synthesis of iguratimod
Project Associate Professor Kitanosono receives the Thieme Chemistry Journals Award
Paper published on the Knoevenagel condensation in water
Paper published on the asymmetric aldol reaction at micelle interfaces in water
ResearchResearch themes
The lab develops environmentally friendly chemical transformation and material transformation methods. Making use of biomass, carbon dioxide, and hydrogen, it develops catalysts and continuous-flow technologies that lead to the production of fine chemicals such as pharmaceuticals and semiconductor materials.
*Illustrative imageOrganic Chemistry in Water
The lab develops reactions that proceed in water instead of organic solvents. It has shown that catalysts combining a Lewis acid with a surfactant create a hydrophobic reaction environment in water.
*Illustrative imageHighly Stereoselective Catalysts
The lab studies catalytic asymmetric synthesis, which suppresses byproducts and selectively produces only the desired form of a molecule. It is also developing reactions that use abundant, inexpensive elements such as calcium.
*Illustrative imageNew Immobilized Catalysts
The lab develops methods in which metal catalysts are enclosed in polymers so that they do not leach out and can be recovered and reused. It also works on immobilizing gold and platinum nanoparticles.
*Illustrative imageNew Reaction Methods
The lab develops reactions that use light energy to activate substrates and catalysts. It creates functional groups that activate substrates that react poorly, and applies them to catalytic reactions.
MembersFaculty
- Project Professor / Professor EmeritusShu KobayashiPublications ↗
- Project Associate ProfessorTetsu TsubogoPublications ↗
- Project Associate ProfessorTaku KitanosonoPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Fluorescense Handful of light” Mateusz Urban / CC BY 4.0 (cropped)
- Organic Chemistry in Water: “File-Water droplet at DWR-coated surface1” Brocken Inaglory / CC BY-SA 3.0 (cropped)
- Highly Stereoselective Catalysts: “Mecoprop-racemic-dimer-from-xtal-labelled-3D-balls” Ben Mills / Public domain (cropped)
- New Immobilized Catalysts: “Ion exchange resin beads” Bugman at English Wikipedia
(撮影:Adam Smith) / Public domain (cropped) - New Reaction Methods: “1.Photocatalysis in oxygen” RainbowDasha / CC BY 4.0 (cropped)
- Related lab (Isobe Lab): “Carbon nanotube (8,8) 3D ball” Jynto / CC0 (cropped)
- Related lab (Oguri Lab): “Fluorescense Handful of light” Mateusz Urban / CC BY 4.0 (cropped)
- Related lab (Yamada Lab): “Potassium ferricyanide and its solution” Leiem / CC BY-SA 4.0 (cropped)
- Related lab (Sasaki Lab): “Platinum crystals” Periodictableru / CC BY 3.0 (cropped)
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