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Akiyama Lab
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A lab using DNA as a material to design nanomaterials that deliver drugs.
AboutAbout the lab
Designing organic materials from the molecular level
The Akiyama Lab aims to design the structures of functional organic materials precisely and rationally, and to apply them in advanced engineering fields such as the environment, devices, and medicine.
Building on organic synthetic chemistry and polymer synthetic chemistry, the lab emphasizes creating new functional molecules and evaluating their functions.
Taking advantage of the strengths of DNA as a nanomaterial, the lab aims at applications in bioanalysis, nanomedicine, and environmental fields.
Specifically, it works on the precise structural design of carrier-free DDS (drug delivery systems) that deliver nucleic acid therapeutics into cells.
Key terms
- DDS
- Drug delivery system. A mechanism for carrying drugs, which plays an important role in blood retention and tumor accumulation.
- Carrier-free DDS
- A DDS that does not use drug carriers such as lipids or polymers. It aims to solve the problem of toxicity of the carriers themselves.
- Combination therapy
- A treatment that administers drugs with different mechanisms of action at the same time. It is expected to be more effective than a single drug and to overcome drug resistance.
ResearchResearch themes
Building on organic synthetic chemistry and polymer synthetic chemistry, the Akiyama Lab designs the structures of functional materials that make use of the strengths of DNA nanomaterials. In particular, it is developing carrier-free DDS that deliver nucleic acid therapeutics to cells without using a carrier.
Carrier-Free Nucleic Acid DDS
The lab is designing the structures of carrier-free DDS formulations that introduce natural-sequence nucleic acid drugs into cells with high efficiency and low toxicity, without cationic polymer or lipid carriers. Using nanoparticles that combine nucleic acid drugs with small-molecule drugs as a base, it aims to develop new nucleic acid therapeutics that achieve both drug stability and safety.
Nano Eye Drops Using Nucleic Acid Therapeutics
Aiming at nano eye drops for eye tumors, the lab studied the design and functional evaluation of nanostructures in which nucleic acid therapeutics are densely arrayed. It built nanostructures with a self-immolative poly(carbamate) core and confirmed that adding a reducing agent promoted their disintegration. It also found that using a gold nanoparticle core with sugars projecting from the surface greatly improved dispersibility, and developed a method to visually detect cancer-related enzymes.
Nanoformulations with Densely Arrayed siRNA
Toward combination therapy, the lab is building nanostructures with densely arrayed siRNA, using nucleobases as components that modify drugs. The goal is to establish the foundational technology for carrier-free nano DDS formulations.
MembersFaculty
- ProfessorYoshitsugu Akiyama
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