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Motomura Lab
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A lab aiming to understand allergic predisposition through innate lymphoid cells and to prevent disease.
AboutAbout the lab
Understanding predisposition to prevent allergies.
To answer the question "Why do people get sick?", the Motomura Lab studies a wide range of diseases, centered on immunological analysis.
In particular, the lab aims to understand the mechanisms of allergic diseases, which have become so common that one in two people has some form of allergy, and to develop treatments that lead to a cure.
The lab focuses on the possibility that innate lymphoid cells, discovered as a new type of lymphocyte, are involved in "allergic predisposition", a state in which people are prone to allergies, and is also working on developing methods to prevent allergies.
Assistant Professor Naoto Ito uses immunology and molecular biology as his research keywords.
Key terms
- Type 2 innate lymphoid cells
- Lymphocytes discovered in 2010. They have no antigen receptors and are activated by substances in the body such as cytokines and lipids
- Type 2 cytokines
- The collective name for IL-4, IL-5, and IL-13. They induce immune responses such as defense against parasite infection, and inflammation in which eosinophils gather
- Pre-disease state
- A stage in which changes occur in the body and accumulate before a disease develops. It does not yet appear as symptoms
NewsLab news
A master's student won the Excellence Award at the second-year master's interim presentations of the Institute for Life and Medical Sciences
The lab's research was featured in the university magazine "Kagaku Forum"
The Motomura Lab was launched
ResearchResearch themes
To answer the question "Why do people get sick?", the lab conducts research on a variety of diseases, centered on immunological analysis. By capturing susceptibility to allergies (predisposition) and the pre-disease state before onset, it aims to lead to disease prevention.
Understanding the pathology of type 2 immune diseases
This research elucidates type 2 immune diseases, such as allergies caused by type 2 cytokines, by focusing on type 2 innate lymphoid cells (ILC2). ILC2 are activated not by allergens but by substances in the body, such as cytokines like IL-33, lipids, and neuropeptides, and cause allergic reactions.
Mechanisms and prevention of allergic predisposition
The lab is attempting to understand scientifically allergic predisposition, which has long been regarded as a vague concept. Centering on ILC2, it aims to identify the factors involved in forming predisposition, develop methods to assess whether someone has the predisposition, and create preventive approaches that target it.
Exploring the pre-disease state before illness
The lab aims to comprehensively understand the pre-disease state before immune-related diseases such as metabolic disease, pulmonary fibrosis, and cancer develop. It creates model mice that spontaneously develop various diseases and, using single-cell analysis and metabolome analysis in addition to immunological methods, captures the changes in the transition from the pre-disease state to disease.
MembersFaculty
The members of the Motomura Lab consist of faculty, postdocs, researchers, doctoral, master's, and undergraduate students, and secretaries.As of 2026
- Associate ProfessorYasutaka Motomura
- Assistant ProfessorNaoto Ito
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