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Terashima Lab
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A lab developing new drugs from molecules that control the movement of immune cells.
AboutAbout the lab
Creating new drugs that can be used starting tomorrow.
The Terashima Lab focuses on chemokines, which control the movement of immune cells, and their receptors, and studies the development of therapeutics for intractable diseases.
The starting point is the question: "How do cells detect abnormalities, gather at sites of disease, and control the disease state?"
The lab targets molecules such as FROUNT, an associated molecule that modulates the intracellular signaling of chemokine receptors, which are a type of GPCR.
Targeted diseases include intractable diseases such as cancer, fibrosis, pain, autoimmune diseases, and lifestyle-related diseases.
Key terms
- Chemokine receptor
- A receptor that receives chemokines, which control the movement of immune cells. One of the GPCRs that govern the immune system
- GPCR
- Short for G protein-coupled receptor. Both immune system receptors and nervous system receptors belong to this group
- FROUNT
- A signaling modulator that works with CCR2 and CCR5, the receptors that control macrophage migration
ResearchResearch themes
How do cells detect abnormalities, gather at sites of disease, and control the disease state? Starting from this question, the lab studies the molecular mechanisms that control the migration, differentiation, and activation of immune cells, and the development of therapeutics for intractable diseases that target them.
The network of chemokines and receptors
The lab focuses on chemokines, which control the movement of immune cells, their receptors, and the chemokine receptor-associated molecules that modulate intracellular signaling. The relationship between chemokines and receptors is not one-to-one but highly redundant, and by clarifying this mechanism, the lab aims to control the signals that worsen disease states. With the cooperation of hospitals, it is also advancing validation studies in clinical research.
Drug discovery that guides signaling back to normal
In evaluating inhibitors of FROUNT, one of the molecules that modulate chemokine receptor signaling, the lab has found potential for use against a wide range of diseases, including cancer, autoimmune diseases, and pulmonary fibrosis. This is drug discovery that aims not simply to suppress or promote signaling, but to guide it back to normal.
Suppressing FROUNT with existing drugs
The lab has found that disulfiram, a drug used to treat alcohol dependence, inhibits FROUNT, suppressing cancer and slowing the worsening of kidney disease.
MembersFaculty
- Associate ProfessorYuya Terashima
VoicesStudent voices
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