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Yoshimura Lab
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The lab aims to develop new cancer treatments starting from NR4A, which controls the brakes of the immune system.
AboutAbout the lab
From the immune system's brakes to new cancer treatments
The Yoshimura Lab works toward new cancer treatments, using the mechanisms that act as the immune system's brakes as its starting point.
The immune system uses negative regulation to avoid reacting to self and harmless substances such as food. This is called immune tolerance.
The lab focuses on the nuclear receptor NR4A family, transcription factors that control the expression of immune brake molecules.
The lab is developing NR4A inhibitors and producing CAR-T cells in which NR4A is suppressed.
Key terms
- Immune tolerance
- A state in which the immune system, through negative regulation, does not react to self or harmless substances such as food
- NR4A family
- Transcription factors that control the expression of immune brake molecules. They belong to the nuclear receptor family
- Anti-PD-1 antibody
- A representative example of an immune brake (negative regulation). It led to Prof. Honjo's Nobel Prize
NewsLab news
View More ↗ResearchResearch themes
Immune tolerance can be seen as negative regulation (the brake) of the positive responses (the accelerator) that drive immunity, and typical examples include anti-PD-1 antibodies. The lab focuses on the nuclear receptor NR4A family, which controls the expression of brake molecules, and aims to develop new cancer treatments.
View More ↗MembersFaculty
- ProfessorAkihiko Yoshimura
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