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Nitta Lab
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The lab explores the basic principles of immunity by studying how T cells are generated in the thymus.
AboutAbout the lab
Solving the basic principles of immunity from the thymus.
The Nitta Lab studies the mechanisms by which T cells are generated in the thymus, an organ of the immune system.
T cells, the command center of the immune system, are selected in the thymus so that only useful cells survive, while harmful cells that react to self are eliminated through cell death.
As a result, T cells that respond to a variety of pathogens but not to self are produced, and the immune system is able to function.
The lab aims to clarify the mechanisms by which T cells are generated in the thymus and to understand the basic principles of the immune system.
Key terms
- Thymus
- The organ where T cells are generated; it plays a central role in the immune system's "self/non-self discrimination"
- T cell
- A cell that acts as the command center of the immune system; it is selected from a population of immature cells within the thymus
- Positive selection
- The mechanism by which only useful cells are selected from a population of immature T cells in the thymus; it is paired with negative selection, which removes harmful cells
NewsLab news
View More ↗ResearchResearch themes
The lab aims to clarify the mechanisms by which T cells are generated in the thymus and to understand the basic principles of the immune system. The thymus is the organ that plays a central role in "self/non-self discrimination," the defining feature of the immune system.
Positive and negative selection of T cells
The lab studies how, within the thymus, only useful cells are selected from a population of immature T cells (positive selection), and harmful cells that react to self are eliminated through cell death (negative selection).
How mRNA vaccines induce T cell immunity
In collaboration with the University of Tokyo, the lab studied how mRNA-lipid nanoparticle (LNP) vaccines induce strong CD8 T cell immunity. It showed that these vaccines use an antigen presentation pathway different from that of conventional vaccines.
MembersFaculty
- ProfessorTakeshi Nitta
- Assistant ProfessorRyunosuke Muro
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