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Koike Lab
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The lab uses organoids made from human iPS cells to explore how organs change with aging.
AboutAbout the lab
Approaching the mechanisms of aging with miniature human organs.
The Koike Lab uses organoids to study how the function of human organs changes with aging.
Organs work through the coordinated action of diverse groups of cells, but there are major limits to directly examining the function of human organs, and how it changes, inside the body.
The lab therefore creates organoids, which can be called miniature versions of human organs, from human iPS cells and primary cells. Focusing on the hematopoietic system and the autonomic nervous system, it investigates age-related functional changes and their molecular mechanisms.
The lab was established in April 2026 at the Research Institute for Biomedical Sciences, Tokyo University of Science.
Key terms
- Organoid
- A three-dimensional tissue made from human iPS cells or primary cells that reproduces a human organ; it can be called a miniature version of a human organ
- Hematopoietic stem cell
- A cell that supplies blood and immune cells throughout life and supports the hematopoietic system
- Niche
- The environment around hematopoietic stem cells, made up of cells and molecules
NewsLab news
View More ↗ResearchResearch themes
The Koike Lab focuses on the hematopoietic system and the autonomic nervous system, studying age-related changes in networks between cells and organs and the restoration of function by controlling them. Using multicellular organoids made from human iPS cells and primary cells, it aims to reproduce and understand the mechanisms of aging and to lead to the development of new interventions.
Aging of hematopoietic stem cells and the niche
Hematopoietic stem cells supply blood and immune cells throughout life, but their properties and the balance of their differentiation change with age. Focusing on the "niche," which consists of surrounding cells and molecules, the lab investigates the cell-cell interactions that determine the state of aged hematopoietic stem cells and the possibility of restoring their function by controlling the niche. It is also building a research foundation for reconstructing the niche environment with organoids.
Aging of the autonomic nervous system and organ function
The lab focuses on the sympathetic nerves, part of the autonomic nervous system, which is distributed to organs throughout the body and regulates their function. It examines how age-related changes in the structure and function of nerves affect tissues such as the liver, skeletal muscle, and bone marrow, and aims to elucidate mechanisms that maintain and restore organ function through interactions among nerves, blood vessels, and immune cells.
Recreating aging with multicellular organoids
From human iPS cells and primary cells, the lab builds multicellular organoids containing multiple cell and tissue components, as well as models combining different tissues. It reproduces and analyzes age-related changes in cell states and in interactions between cells and between tissues. The aim is to clarify the mechanisms that drive aging and to establish a research foundation for evaluating the effects of candidate factors and interventions.
MembersFaculty
The members of the Koike Lab consist of faculty, master's and undergraduate students, and collaborators.As of 2026
- ProfessorHiroyuki Koike
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