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Ikawa Lab
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The lab is an immunobiology lab that investigates how T cells and B cells are generated from hematopoietic stem cells.
AboutAbout the lab
From how lymphocytes are born to new therapies.
The Ikawa Lab studies how T cells and B cells (lymphocytes), the command centers of the immune response, are generated from hematopoietic stem cells.
In adults, hematopoietic stem cells reside in the bone marrow and are maintained throughout life. T cells differentiate and mature in the thymus, and B cells in the bone marrow.
To uncover this mechanism, the lab uses a variety of methods, from the level of genes and cells to the level of whole organisms.
Based on the findings, the lab aims to develop new therapies such as regenerative medicine and immune cell therapy.
Key terms
- Lymphocyte
- The collective name for T cells and B cells, the command centers of the immune response. Both are generated from hematopoietic stem cells.
- Hematopoietic stem cell
- The cell that gives rise to T cells and B cells (lymphocytes). In adults, it resides in the bone marrow and is maintained throughout life.
- Thymus
- The site where T cells differentiate and mature. B cells differentiate and mature in the bone marrow.
ResearchResearch themes
The lab aims to clarify how lymphocytes are generated from hematopoietic stem cells and, based on that knowledge, to develop new therapies such as regenerative medicine and immune cell therapy. The university's lab introduction lists the following as example themes: the regulatory mechanisms of differentiation from hematopoietic stem cells to lymphocytes; transcriptional, epigenomic, and metabolic regulation in immune cell differentiation; the mechanisms underlying the onset of hematologic malignancies; and the development of immune cell therapy using artificial leukocyte stem (iLS) cells.
View More ↗MembersFaculty
- ProfessorTomokatsu Ikawa
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