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Tokinoya Lab
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A lab that explores the effects of exercise on the body through exercise physiology and biochemistry.
AboutAbout the lab
Searching for the answer to 'Is exercise really good for health?'
The Tokinoya Lab studies the effects of exercise from the perspective of exercise physiology and biochemistry, and also conducts analyses using molecular biology methods.
Many people believe that exercise is good for health, but much about its effects is still unknown. The lab carries out research to find the answers in its laboratory on the campus in Hodogaya Ward.
Focusing on a substance called renalase, the lab investigates the mechanism by which exercise has beneficial effects against the age-related decline in mitochondrial function in skeletal muscle.
The lab got fully underway in fiscal 2025.
Key terms
- Renalase
- A physiologically active substance newly discovered in 2005 as a secretion of the kidney. Its level rises in skeletal muscle after exercise.
- Early-onset muscle pain
- Muscle pain that appears right after a full marathon. Assistant Professor Tokinoya showed that it starts to appear around the 20 km point and named it.
NewsLab news
View More ↗ResearchResearch themes
The Tokinoya Lab studies the effects of exercise on the body from the perspective of exercise physiology and biochemistry. Its research overview introduces three topics: renalase in skeletal muscle, the body's responses to long-distance running such as a full marathon, and measurements using saliva.
Exercise and renalase in skeletal muscle
In exercise experiments, Assistant Professor Tokinoya has detected renalase in the blood and has shown results suggesting that its secretion originates from skeletal muscle. He has also found that training increases gene expression in skeletal muscle, along with results on skeletal muscle cell proliferation.
The body's responses to a full marathon
The lab studies the dynamics of muscle pain and muscle damage in long-distance running. It found that the muscle pain felt right after a full marathon starts to appear around the 20 km point, and named it early-onset muscle pain. It has also shown results on urinary biomarkers of the kidney after a full marathon, and results showing that taking maslinic acid reduces muscle pain and fatigue the next day.
Measuring responses to exercise with saliva
The lab is designing and conducting experiments so that many of the physiological responses that occur during exercise can be monitored through saliva.
MembersFaculty
- Assistant ProfessorKatsuyuki Tokinoya
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